Monthly Archives: June 2019

AlternaScript – Featured Brand

AlternaScriptSusan Brown Health and Wellness Editor

Professional Supplement Center now offers AlternaScript, a line of scientifically advanced supplements designed to optimize health and wellness. An Austin, Texas based health tech company, AlternaScript teams with scientists, microbiologists, dieticians and physicians to identify and utilize efficacious ingredients and create synergistic products that work with the body to promote health. For the best possible outcomes, products are formulated with clinically tested, science backed ingredients and are manufactured under GMP regulations.

AlternaScript works with select charities and donates 5% of their profits to recovery centers, rehabilitation programs and counseling for families affected by off-label prescription drug abuse.

For more information on AlternaScript products, please visit professionalsupplementcenter.com

OptiMind®OptiMind®: OptiMind® is formulated with carefully selected, clinically tested ingredients to promote enhanced cognitive performance, focus and energy. Ingredients include bioavailable vitamins D3 and B12, amino acids, calcium and magnesium, as well as plant-based components phosphatidylserine, bacosides, huperzine A and tyrosine. Contains soy and caffeine.

NuCulture™NuCulture™: Each capsule of NuCulture™ provides 15 billion CFU of five clinically studied probiotic stains, including Bacillus subtilis, a patented spore-forming strain, in support of healthy intestinal microflora. PreforPro® prebiotic targets harmful bacteria, while providing food to help beneficial bacteria thrive. Patented, delayed-release capsules protect probiotics from the harsh stomach environment to aid colonization in the digestive tract.

NatureThin™NatureThin®: This vegetarian, scientifically engineered formulation provides clinically tested ingredients to support healthy weight maintenance. Ingredients include vitamins, minerals and Slimvance™, a proprietary botanical blend.

 

Rest Up®Rest Up: These clinically tested, non-habit forming sublingual tablets are designed to promote relaxation and healthy sleeping habits. Ingredients include L-theanine, 5-HTP, magnesium and melatonin to help stabilize the sleep/wake cycle for restful sleep, as well as provide cellular energy support for rejuvenation.

Glutamine and the Gut

Glutamine and the GutJacquie Eubanks RN BSN

Glutamine, the most abundant and versatile free amino acid in the body, also appears to be the most active amino acid due to its involvement in numerous metabolic functions. It plays a vital role in protein and glutathione synthesis, energy production, immune function and the maintenance of optimal antioxidant status. Essential for maintaining intestinal function and mucosal integrity, as well as the repair and maintenance of gut barrier function, glutamine is a precursor for the synthesis of proteins, ribonucleotides and vitamins and also serves as a major energy source for cell division by providing nitrogen when glucose is low. As well, glutamine aids in the maintenance of normal blood glucose and proper acid/base balance.

As a main fuel source for a large number of cells, amino acid availability is fundamental to cell survival, maintenance and proliferation. The majority of glutamine is synthesized and stored in the muscles and lungs, and is released into circulation by key metabolic organs, including the gut, liver and skeletal muscles. Glutamine is so essential to immune function that the rate of glutamine consumption by immune cells, which often function under nutrient restricted microenvironments, is comparable to or greater than that of glucose. The body’s biochemical and metabolic pathways control pathogen infections by increasing amino acid catabolism, aiding immune response and helping to control inflammatory responses to infections.

Recent studies have highlighted the critical role of glutamine in the maintenance of intestinal barrier integrity. It is estimated that during a normal lifetime, 60 tons of food passes through the gastrointestinal tract, posing a continuous threat to the integrity of the multifunctional, rapidly proliferating epithelial cells that line mucosal walls. A healthy functioning gut barrier is essential for the absorption of nutrients and the rejection of pathogens, toxins and allergens. Mucosal barrier dysfunction is associated with increased gut permeability and the development of multiple gastrointestinal and autoimmune diseases. Glutamine is reported to enhance intestinal absorptive cell proliferation and regulate intestinal barrier function during injury, infection and other conditions.

Growing evidence supports the theory that glutamine is a nutritionally essential amino acid for newborns and a conditionally essential amino acid for adults. As a functional amino acid with multiple physiological roles, glutamine may protect the gut from atrophy and injury from a diverse number of stress-related conditions characterized by chronic inflammation, such as stomach ulcers, irritable bowel syndrome, ulcerative colitis and Crohn’s disease. It’s theorized that chronic stress can lead to a poorly functioning immune system and change the balance of the gut microbiota, allowing ulcer-inducing H. pylori and other harmful bacteria to thrive.

Traditionally termed a nonessential amino acid, glutamine is normally synthesized by the body in adequate amounts. However, given the importance of glutamine in maintaining normal cellular functions, glutamine is considered a conditionally essential amino acid when the body’s consumption of glutamine exceeds the rate of production. This may occur during times of increased demand, particularly post-surgery or traumatic injury, during critical illness or metabolic stress, a physiological process that occurs during exercise in response to athletic exhaustion. In addition to synthesis, glutamine is a naturally occurring amino acid obtained from dietary sources, including animal proteins, such as chicken, seafood and dairy, and plant- based proteins, including beans, leafy greens, tofu, beets and lentils. As glutamine stores are depleted during illness and metabolic stress and the intestines utilize about 30 percent of total glutamine, supplementation when indicated may improve clinical outcomes for intestinal, immune and overall health.

Professional Supplement Center offers these and other high quality supplements in support of immune, intestinal and overall health:

L-Glutamine 1,000 mgL-Glutamine 1,000 mg by Pure Encapsulations®: This hypoallergenic formulation provides nutritional support for enhanced mucosal lining health, intestinal integrity and a healthy functioning gastrointestinal tract, as well as lean muscle mass growth and maintenance. Gluten free, Non-GMO vegan formulation.

L-Glutamine PowderL-Glutamine Powder by Designs for Health®: This professional powdered formulation provides 3 g of L-glutamine per serving for immune and digestive support, as well as maintenance and growth of lean muscle mass. Gluten free, Non-GMO formulation.

Glutamine ForteGlutamine Forte by Integrative Therapeutics®: Each serving of this naturally flavored powdered formula provides 5 g of L-glutamine blended with 100 mg of bioavailable turmeric, supporting enhanced immune function and the restoration and maintenance of healthy gut barrier function and permeability. Free of sugar, salt, yeast, wheat, gluten, soy, dairy and artificial coloring, flavoring and preservatives. Vegetarian formulation.

L-Glutamine CapsulesL-Glutamine 500 mg by Designs for Health®: Each capsule provides 850 mg of L-glutamine, supporting  immune and digestive tract health, as well as optimal muscle growth and maintenance. Gluten and soy free, Non-GMO vegetarian formulation.

 

References:
Glutamine: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/glutamine
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266414/
Glutamine and intestinal barrier function. https://www.ncbi.nlm.nih.gov/pubmed/24965526
Role of glutamine in Protection of Intestinal Epithelial Tight Junctions. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369670/
Glutamine supplements show promise in treating stomach ulcers. https://news.harvard.edu/gazette/story/2009/05/glutamine-supplements-show-promise-in-treating-stomach-ulcers/

The Benefits and Actions of Vitamin B3

Vitamin B3Jacquie Eubanks RN BSN

As a member of the family of eight B vitamins, vitamin B3, or niacin, has a wide range of uses in bodily functions. The different forms of niacin include nicotinic acid and niacinamide/nicotinamide, each of which provides health benefits supported by scientific studies. Like other B vitamins, B3 is water soluble and, as such, is not stored by the body and must be obtained daily from the diet or supplementation. Largely found in animal protein, as well as nuts, legumes and grains, individual niacin levels depend on the amount and quality of dietary intake. When the intake of protein is at a sufficiently high level, the body can biologically convert the amino acid tryptophan to nicotinic acid or nicotinamide, although the conversion rate will vary with each individual.

Essential to all forms of life, the nicotinamide coenzyme NAD+ is synthesized in the body from four precursors that are provided by an adequate healthful diet: nicotinic acid, nicotinamide, nicotinamide riboside, and tryptophan. As blood levels of niacin are not reliable indicators, niacin status is measured by the urinary excretion rates of its two major methylated metabolites, chemical compounds formed as part of the natural biochemical process of metabolism. More than 400 enzymes require niacin coenzymes for biological functions. These include:

  • Energy production reactions involving the breakdown of carbohydrates, fats, proteins and alcohol
  • The synthesis of fatty acids, cholesterol, bile acids and steroid hormones
  • The building blocks of proteins, lipids, polysaccharides and nucleic acids
  • The regeneration of components of detoxification and antioxidant systems

An attractive option for those with dyslipidemia, nicotinic acid has been utilized therapeutically for more than 50 years. Dyslipidemia is characterized as an elevation of blood levels of cholesterol and/or triglycerides and frequently a low level of HDL cholesterol. Dyslipidemia can lead to increased risk of stroke, atherosclerosis and coronary artery disease, as well as peripheral artery disease, a narrowing of the arteries that can limit blood flow to the limbs, the legs in particular. Treatment involves dietary improvements, weight loss, increased physical activity and often, lipid-lowering pharmaceuticals. Niacin (nicotinic acid) has been shown to safely and effectively address lipid abnormalities by increasing HDL cholesterol and lowering LDL cholesterol and triglycerides.

Niacin has a proven safety record and an ability to be safely combined with statin medication.  Nicotinic acid therapy can result in short-lived, but bothersome non-allergenic, dermal flushing, characterized by redness and warmth and sometimes tingling or itching. However, tolerance to niacin-induced flushing often develops rapidly, and abates when a constant blood level of niacin is reached. As well, a higher rate of flushing, which generally lasts an hour or two, is associated with a higher rate of niacin absorption.

Nicotinamide and nicotinic acid are similarly effective as a vitamin, as they can be converted into each other within the body. Nicotinamide, or niacinamide, prevents deficiency and performs all of the essential functions of niacin. However, as a result of its slightly different chemical structure, niacinamide does not cause flushing nor provide cholesterol lowering benefits. Often overlooked for its skin care benefits, nicotinamide significantly reduces the incidence of nonmelanoma skin cancers in those with a history of basal cell carcinoma or squamous cell carcinoma.

In aging skin, topical application of niacinamide improves the surface structure, smooths out wrinkles and inhibits photocarcinogenesis, protecting the skin from damage caused by ultraviolet rays. This form of B3 helps to brighten the complexion, decreases hyperpigmentation, supports healthy collagen production, calms inflammatory conditions, such as acne or rosacea, and offers verifiable stabilizing effects on epidermal barrier function.

Additionally, anxiety is one of the manifestations of severe B3 deficiency. In clinical observations, niacinamide supplementation above a nutritional dose has been shown to relieve anxiety in some individuals. The anti-anxiety effect of niacinamide is presumed to be pharmacological, as it appears to have medicinal properties similar to benzodiazepines. These effects may be exerted through the modulation of brain neurotransmitters associated with anxiety. Although further studies are warranted to assess niacinamide’s actual therapeutic effects, this agent does appear to have a wide spectrum of beneficial influences upon anxiety disorders.

Professional Supplement Center offers these and other high quality supplements in support of overall good health:

Niatab™ 500Niatab™ 500 by Douglas Laboratories®: For maximum benefit and to reduce the effect of skin flushing or itching, Niatab™ delivers 500 mg of niacin over a two to three hour time period. The scored uncoated tablets may be halved for lower dosing. Soy free, vegan formulation.

Time Release NiacinTime Release Niacin by Professional Supplement Center®: Time Release Niacin provides 500 mg of niacin as nicotinic acid over a seven to eight hour time period, while reducing the flushing effect. Free of gluten, corn, yeast and artificial colors and flavors.

 

NiaCel-250NiaCel-250® by Thorne®:  (log-in) Each serving of NiaCel-250® provides 250 mg of nicotinamide riboside for nutritional support of energy production, healthy metabolic function, weight management and exercise endurance. Free of gluten, soy, lactose, eggs, aspartame, high fructose corn syrup, sucralose and stearates. Non-GMO vegetarian formulation.

Niacinamide 500 mgNiacinamide 500 mg by Douglas Laboratories®: Each capsule provides 500 mg of niacin as niacinamide in support of healthy bodily functions and overall wellness. Gluten and soy free. Non-GMO formulation.

 

References:
The mechanism and mitigation of niacin-induced flushing. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779993/
Nicotinic acid/niacinamide and the skin. https://www.ncbi.nlm.nih.gov/pubmed/17147561
Niacin: Nicotinic Acid, Nicotinamide, and Inositol Hexanicotinate. https://www.crnusa.org/sites/default/files/files/resources/13-CRNVMS3-NIACIN.pdf
Niacin and heart disease prevention: Engraving its tombstone is a mistake. https://www.lipidjournal.com/article/S1933-2874(17)30410-5/fulltext
Supplemental Niacinamide Mitigates Anxiety Symptoms: Three Case Reports. https://pdfs.semanticscholar.org/0c55/ebbffdc0832e531976a6f665c60831d58202.pdf