Tag Archives: 5-HTP

Fibromyalgia

FibromyalgiaJacquie Eubanks RN BSNInvisible to the eye, Fibromyalgia is a chronic disorder characterized by symptoms of widespread muscle, tendon, ligament and body pain often accompanied by tenderness in specific areas of the body known as tender points. In many cases fibromyalgia may be initially misdiagnosed, as individuals generally experience a range of symptoms that can include joint stiffness, sleep disturbances, headaches, cognitive and memory issues, depression, irritable bowel, whole body fatigue and more. Lab tests are often used to rule out other possible co-existing conditions. Fibromyalgia can affect anyone. Yet, for unknown reasons most of those diagnosed with the disorder are adult women.

Although fibromyalgia may be attributed to a number of factors, exact causes remain a mystery. The disorder is frequently attributed to traumatic events that can be physical, emotional or medical, such as a motor vehicle accident, a traumatic life event, or an illness or infection. Hormonal disturbances linked to chronic stress, and autoimmune diseases such as rheumatoid arthritis or lupus may also be contributing factors. Genetic mutations are believed to play a role, as those with a family history of the syndrome are at greater risk for developing the condition.

Fibromyalgia is a life-altering centralized persistent pain state that varies in intensity from day to day. A multi-disciplinary team approach for the management and relief of symptoms is often recommended, as currently, underlying causes are not identified and addressed. As the body is designed to heal and health is the natural state, affected individuals must play an active role. Self-management strategies may help to reduce the frequency, duration and intensity of periodic flare-ups. Although fibromyalgia results in painful and uncomfortable symptoms, the condition is not life-threatening and doesn’t result in organ or muscle damage.

Like the management of other chronic conditions, healthy daily lifestyle habits can help with symptom relief, minimize the impact on one’s life, and lower the risk for other health problems. Conventional approaches include medication, exercise and physical therapy. A more balanced approach includes complementary and alternative therapies. Supplements, along with lifestyle changes and other treatments, have been shown to help lessen pain, increase energy and promote healthier sleep.

Pain relief: Take medications as prescribed. Over the counter pain relievers should only be used as needed for as short a time as possible. A long soak in the tub with added Epsom salts can help to reduce deep muscle pain and promote better sleep.

Stress reduction: Focus on recognizing and reducing signs of stress, such as shoulder tension and headaches. Restorative yoga and meditation may help to lower stress and reduce pain.

Physical activity: Due to pain and fatigue, many find it difficult to be physically active. Yet, research has shown that daily activity is one of the most effective treatments for fibromyalgia. Develop a low-impact exercise routine to help reduce pain, increase energy, reduce stress and aid more restful sleep. Walking and water aerobics for a short period a few days a week are good starting points. As pain decreases and energy increases, one may gradually increase frequency and intensity.

Sleep management: Pain makes it difficult to get restful sleep, and lack of sleep can exacerbate symptoms. Getting sufficient sleep can help to ease pain and fatigue. Establish a healthy bedtime routine and avoid afternoon naps, as well coffee, alcohol and stimulating exercise within three hours of bedtime.

Nutrition: A balanced healthy diet and proper nutrition supports energy production and good health, and reduces the risk of developing other chronic conditions. Although no specific diet for fibromyalgia has been identified certain dietary strategies, such as eating more plant foods, reducing animal foods, staying hydrated, and reducing sugar intake, support overall wellness. Fermented foods and foods rich in omega-3 fats and antioxidants can keep the digestive system on tract, and reduce inflammation and oxidative stress.

Alternative therapies: Massage therapy, yoga, tai chi, acupuncture and chiropractic manipulation may be helpful to relieve pain, reduce stress, improve function and promote natural healing.

Dietary supplements commonly used to treat fibromyalgia symptoms include:

D-ribose: D-ribose is a naturally occurring unique sugar used by all bodily cells to build energy. Well-tolerated in supplemental form, D-ribose has been shown to increase cellular energy synthesis in heart and skeletal tissue. A pilot study found that D-ribose significantly improved energy, sleep, mental clarity, pain intensity, and wellbeing in those with fibromyalgia and chronic fatigue syndrome.

SAMe: Naturally produced by the body, SAMe boosts levels of serotonin and dopamine, which may help improve mood, and relieve pain, morning stiffness, and fatigue. Harvard Medical School researchers have found that SAMe is safe and effective for treating symptoms of mild depression.

5-HTP: This natural amino acid is used by the body to produce serotonin, a neurotransmitter that helps to regulate mood and behavior. Many individuals with fibromyalgia have low levels of serotonin. 5-HTP may have a positive effect on sleep, mood, anxiety, appetite, and pain sensation.

Magnesium: Magnesium deficiency is linked to fibromyalgia symptoms. Maintaining therapeutic blood levels of magnesium is associated with a lessening of symptoms of depression, tender point soreness, and fatigue.

Vitamin D: A review of published studies found that vitamin D levels may play a key role in the relationship between pain and sleep. Researchers theorize that vitamin D supplementation combined with good sleep hygiene could increase the effectiveness of pain management treatments in fibromyalgia and other pain related conditions.

Adaptogenic herbs: Adaptogenic herbs such as ashwagandha and rhodiola help to improve metabolic and cognitive function, and defend against the negative consequences of stress by inhibiting the release of cortisol, a stress hormone.

Professional Supplement Center carries these and other high quality formulations to address symptoms of fibromyalgia:

Corvalen Ribose...Corvalen® Ribose Chewable Tablets by Douglas Laboratories®: These all-natural D-ribose chewable tablets are clinically proven to help restore energy, support cardiac function, and reduce muscle stiffness, soreness, and fatigue. D-ribose helps to reduce energy loss in times of stress, and accelerates muscle and tissue recovery after exercise. Gluten, soy, wheat, dairy and artificial ingredient free, vegan formulation.

5-HTP 100 mg (5...5-HTP 100 mg by Pure Encapsulations®: Clinically studied 5-HTP supports and encourages brain serotonin levels that can lead to positive effects on emotional wellbeing, appetite control, and wake/sleep cycles. Gluten and soy free, Non-GMO vegetarian formulation.

Malic Acid +...Malic Acid + Magnesium Tablets by Douglas Laboratories®: This formula blends malic acid, a naturally occurring organic acid, with magnesium, vitamin C and bioflavonoids. These synergistic ingredients may have a beneficial effect on fibromyalgia symptoms, as well as the healthy structure and function of the immune and skeletal systems. Gluten, soy, dairy and artificial ingredient free.

Bio-D-Mulsion ForteBio-D-Mulsion Forte® by Biotics® Research: Designed to be helpful for those with absorption issues, this formula provides vitamin D3 in a highly bioavailable, micro-emulsified form for enhanced absorption and utilization. Gluten free.

 

Bio-Adaptogen UltraBio-Adaptogen™ Ultra by Nutra BioGenesis®: This professional ayurvedic blend of adaptogenic herbs provides nutritive support during times of stress, and supports healthy adrenal function, optimal energy levels, and overall wellbeing.

 

Magnesium (glycinate...Magnesium Glycinate by Pure Encapsulations®: Important for numerous bodily functions, this product supplies highly bioavailable magnesium chelate along with vitamin C. Less likely to cause bowel discomfort than other forms of magnesium, magnesium in glycinate form provides support for neuromuscular and cardiac function, mood balance, and the proper metabolism and utilization of essential nutrients. Gluten and soy free, Non-GMO vegetarian formulation.

References:
Questions and Answers about Fibromyalgia. https://www.niams.nih.gov/health_info/fibromyalgia/
What is Fibromyalgia? https://www.fmcpaware.org/aboutfibromyalgia.html
Fibromyalgia. https://familydoctor.org/condition/fibromyalgia/?adfree=true
Everything You Need to Know About Fibromyalgia. http://www.healthline.com/health/fibromyalgia#is-fibromyalgia-real1
Fibromyalgia: Symptoms, causes, and treatment. http://www.medicalnewstoday.com/articles/147083.php
7 Natural Remedies for Fibromyalgia: http://www.healthline.com/health-slideshow/fibromyalgia-natural-remedies#1
Magnesium and its Role in Fibromyalgia Treatment. http://www.fmaware.org/about-fibromyalgia/magnesium-fibromyalgia-treatment/
The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. https://www.ncbi.nlm.nih.gov/pubmed/17109576
Vitamin D Supplements, Quality Sleep Could Help Relieve Symptoms of Fibromyalgia, Other Chronic Pain Conditions. https://fibromyalgianewstoday.com/2017/06/07/fibromyalgia-chronic-pain-may-be-relieved-by-vitamin-d-supplements-qual/

 

All About GABA

gabaJacquie Eubanks RN BSN

As the body’s major inhibitory neurotransmitter, GABA is widely distributed and utilized throughout the central nervous system. Glutamate, an excitatory neurotransmitter, is the most common neurotransmitter and the metabolic precursor of GABA. GABA works to calm overexcited neurons, counterbalancing glutamate’s effects and helping to keep anxiety and brain overstimulation in check. While some neurotransmitters have dual functions–both excitatory and inhibitory–GABA functions solely as a calming agent, supporting optimal brain function and reining in fear and anxiety. In fact, pharmaceutical medications designed to alleviate anxiety work by targeting the GABA system, binding to GABA receptors in the brain, and enhancing GABA’s natural relaxing effects.

As GABA is the main inhibitory and glutamate the main excitatory neurotransmitter, GABA and glutamate have a complex and interconnected relationship. Each must perform a delicate dance to provide a stable, steady and well-functioning brain environment under normal conditions. Glutamate must be present in the right concentration and be in the right place at the right time for proper functioning. As the major mediator of excitatory signals, glutamate is responsible for many aspects of normal brain functioning including cognition, memory and learning. In addition, glutamate must also mediate the information that regulates brain development and cellular survival. When there is either excess or insufficient glutamate, mental wellness and physical health are affected.

Although glutamate is one of the most abundant and powerful neurotransmitters, it is almost exclusively located within the brain’s nerve cells, where it remains relatively inactive until extracellular glutamate binds with receptors. When glutamate levels are abnormally high or receptors are oversensitive, nerve cells activated by glutamate become overexcited, which can lead to glutamate toxicity, neurological inflammation and cellular exhaustion. Chronic glutamate toxicity can affect nerve cell survival and brain function and is believed to play a role in numerous neurodegenerative disorders, including Alzheimer’s and Huntington’s diseases.

GABA’s primary function is to prevent overstimulation. An imbalance of GABA and glutamate can leave you feeling depressed, overwhelmed, anxious, restless, nervous and sleepless. Low serotonin levels result in low GABA levels, as serotonin is a positive regulator of the interaction between GABA and GABA receptors. Factors that contribute to GABA insufficiency include genetics, inadequate diet, and prolonged stress. In addition to a healthy diet, that includes green vegetables, whole grains, nuts, fermented foods, and citrus fruits. Certain supplements, including the amino acid taurine, can support GABA receptors and encourage GABA formation. Exercise, such as yoga, is believed to help to increase GABA production, which may help to explain its calming and stress relieving effects.

Just like all cells, organs and metabolic processes, neurotransmitters require vitamins, minerals, amino acids and phytonutrients for effective function:

Taurine – As an amino acid, taurine freely crosses the blood brain barrier and is a positive GABA modulator with no side effects. Taurine has been shown to prevent neuronal damage, that can occur through increased glutamate levels, and significantly reduce neuron death associated with overstimulation.

L-Theanine – This plant-based amino acid found in tea increases brain levels of GABA, while enhancing receptor response. Studies have shown that L-theanine is useful for improving sleep quality, calming the central nervous system, and counteracting the toxic effects of stress.

Magnesium – Magnesium binds to and activates GABA receptors helping to relieve anxiety, insomnia, irritability and nervousness.

Vitamin B6 – Vitamin B6 is key to GABA synthesis and is used to help regulate GABA levels. GABA is formed from glutamic acid, utilizing B6 as a cofactor.

5-HTP – As a precursor to serotonin production, 5-HTP can help increase GABA activity. Adequate serotonin is needed for proper GABA function.

While researchers continue to study the effects of supplementation, scientists have studied GABA’s effects on brain waves. One study concluded that GABA significantly increased alpha waves and decreased beta waves, denoting that GABA effectively induced relaxation and reduced anxiety within one hour after supplementing. Another study showed that in addition to   encouraging relaxation and diminishing anxiety, GABA may enhance immunity under stressful situations.

Professional Supplement Center carries these and other high quality products to support overall wellness.

NeuroAdrenal...NeuroAdrenal Essential by Pharmasan Labs – This at-home test kit measures cortisol and select neurotransmitters, including GABA, glutamate, dopamine, serotonin and norepinephrine. Simply collect urine and saliva specimens in the privacy of your home and send them off in the prepaid packaging. Laboratory results are typically available within 7-10 days. A 15-minute follow-up consultation with our registered nurse is included with the test kit.

 

Calm GCalm G by NeuroScience – Calm G, formulated with neuron protecting ingredients, is used to reduce anxiousness, promote sleep and support healthy GABA levels. Calm G helps to modulate GABA-glutamate levels to calm overstimulation. Gluten, soy and yeast free formulation.

 

Trancor®Trancor® by Metagenics – This GABA-glutamate balance formula supports tranquility by modulating the balance between these two neurotransmitters. Supplies NAC, vitamin B6, magnesium, taurine, and green tea catechins. Gluten free formulation.

 

Gaba 750 mgGABA 750 by Integrative Therapeutics – One serving provides 750 mg of GABA in support of healthy brain nerve cell functions and healthy neurochemical balance. Gluten, soy and dairy free, vegetarian  formulation.

 

Taurine 1000 mgTaurine 1000 mg by Designs for Health – This sulfur containing amino acid is essential for glucose metabolism and healthy heart, immune, and nervous system functions. Gluten, soy and dairy free formulation.

References:
GABA Receptor Physiology and Pharmacology. https://www.ncbi.nlm.nih.gov/books/NBK28090/
Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. https://www.ncbi.nlm.nih.gov/pubmed/16971751
GABA and glutamate in the human brain. https://www.ncbi.nlm.nih.gov/pubmed/12467378
Glutamate as a Neurotransmitter.  http://neurotransporter.org/glutamate.html
Glutamate Toxicity. http://web.stanford.edu/group/hopes/cgi-bin/hopes_test/about-glutamate-toxicity/
Chronic Glutamate Toxicity in Neurodegenerative Diseases. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679930/