Tag Archives: Curcumin 500 with Bioperine® by Pure Encapsulations

Curcumin

CurcuminJacquie Eubanks RN BSN

Utilized throughout history for many purposes, plants evolved to produce secondary metabolites as natural defense mechanisms against disease and infection. Many plants have pharmacological or biological activities that have played a role in health care, from plant-based medicines to healthy cuisines. One such plant, Curcuma longa, has been used traditionally in Ayurvedic and Chinese medicine for well over 2,000 years. A close relative of the ginger family, this rhizomatous herbaceous perennial plant has long been prized for its anti-inflammatory, antioxidant, anti-carcinogenic, anti-mutagenic, anticoagulant, antibacterial, antiviral, antimicrobial and hypotensive properties. Additionally, turmeric activities have been shown to be cardio-, hepato-, nephro- and radioprotective. Turmeric, the bright yellow-orange aromatic powder, is obtained from the rhizome of the plant. The bioactive compounds it contains come mainly from fat-soluble, polyphenolic pigments known as curcuminoids. Curcumin, the principal curcuminoid, is generally considered its most active constituent.

Per the National Institutes of Health (NIH), curcumin aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety and hyperlipidemia. It may also enhance performance and recovery in active people with exercise-induced inflammation and muscle soreness. Its antioxidant and anti-inflammatory effects are seen to provide therapeutic benefits in heathy persons, as well as those with health challenges. Similar to vitamin E, curcumin’s antioxidant activity has been shown to improve systemic markers of oxidative stress due to an efficient ability to scavenge and neutralize free radicals. Oxidative stress is implicated in many chronic inflammatory diseases and conditions, including diabetes, obesity, asthma, colitis, depression and arthritis, as well Alzheimer’s, Parkinson’s and cardiovascular diseases.

The pathological processes of oxidative stress and inflammation are closely related. Inflammatory cells release free radicals at the site of inflammation leading to oxidative stress, while free radicals enhance pro-inflammatory gene expression. Curcumin has been shown to inhibit pro-inflammatory pathways, as well as mediators of the inflammatory response. Curcumin has been extensively studied in both modern and Ayurvedic medicine for treatment of various medical conditions, including some cancers, atherosclerosis, liver diseases and arthritis. It has also been utilized in treatment of traumatic brain injury and dementia. Ongoing studies will continue regarding the potential role of curcumin in the prevention and treatment of Alzheimer’s, as curcumin’s antioxidant, anti-inflammatory and lipophilic actions appear to aid and improve the cognitive functions of those with Alzheimer’s disease.

Curcumin has relatively poor bioavailability possibly due to poor absorption, rapid metabolism, and speedy elimination. However, when combined with components such as black pepper, the bioavailability greatly increases. Black pepper contains piperine, a compound that inhibits drug detoxifying enzymes, including the metabolic breakdown of turmeric compounds in the liver and digestive tract. This allows the curcuminoids to remain in the body for a longer time, thereby increasing the bioavailability of the curcuminoids. Additionally, turmeric or curcumin is best taken with a meal that contains fats or oils to aid in the enhanced absorption of the beneficial properties. When consumed with fat, curcumin is directly absorbed into the bloodstream through the lymphatic system, bypassing the liver, which actively attempts excretion through urination.

The beneficial effects of turmeric are traditionally achieved through dietary consumption, even at low levels, over a period of time. The traditional use of turmeric has been known to be safe for centuries. To date, no studies have discovered any toxic effects associated with turmeric use even at high doses. Phytochemical analysis of turmeric has isolated more than 100  components, many of which have potent pharmacological properties, including curcumin, volatile oil and curcuminoids.

Always check in with your healthcare provider before taking curcumin or turmeric, especially if you are taking medications or have a health condition. Supplements may increase the effects of several pharmaceutical drugs, including blood-thinning and blood-sugar lowering medications.

Professional Supplement Center offers these and other high quality formulations for overall health support:

Turmeric Plus

Turmeric Plus by Nutritional Frontiers: This professional botanical formulation provides turmeric rhizome extract along with Bioperine® in support of free radical protection and digestive, circulatory and blood vessel health.

 

Curcumin 500 with...Curcumin 500 with Bioperine® by Pure Encapsulations®: This formula provides Curcuma longa root extract along with Bioperine® in support of the body’s natural inflammatory response, as well as healthy liver, colon, musculoskeletal and cellular function. Gluten free, Non-GMO, hypoallergenic formulation.

 

Turmeric Extract,...Turmeric Extract Full Spectrum® by Planetary™ Herbals: Planetary Herbals Full Spectrum™ Turmeric Extract consists of a concentrated turmeric extract, standardized to 95% curcuminoids, and whole turmeric rhizome. This captures a broad range of turmeric constituents in support of antioxidant protection and a healthy inflammatory response. Sourced from Certified Organic turmeric roots. Available in tablets or in a proprietary liquid blend.

 

Curcumin Extract 500...Curcumin Extract 500 mg by Vital Nutrients: This potent antioxidant formulation supports normal tissue and overall health and provides free radical defense. Free of coatings, binders, gluten, dairy, soy, eggs, and sugar. Independently tested for authenticity, potency, heavy metals, residues, and toxins.

 

Curcumin Pro-95Curcumin Pro-95 by Professional Supplement Center®: This powerful blend provides BCM-95® comprising 95% total curcuminoids, curcumin and volatile oils in support of antioxidant and cell-protective activity, and brain and neuronal health, as well as a healthy microbial environment. Free of wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, eggs, GMOs, and artificial colors, sweeteners, and preservatives.

References:
Turmeric, the Golden Spice. https://www.ncbi.nlm.nih.gov/books/NBK92752/
Curcumin: A Review of Its Effects of Human Health. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/
Bruno, Gene, MS, MHS, RH. Curcumin and Cardiovascular Health. Vitamin Retailer, November 2017.
Curcumin. https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/curcumin
The effect of curcumin (turmeric) on Alzheimer’s disease: An overview. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/
Why Turmeric and Black Pepper Is a Powerful Combination. https://www.healthline.com/nutrition/turmeric-and-black-pepper

Brain Nutrients – Food for Thought

FoodForThoughtJacquie Eubanks RN BSN

While we primarily conceive of nutrition in terms of energy production and support for building and repair processes, throughout history, many cultures have traditionally used plant foods and spices as a means for prevention and protection against disease. In modern times, the ability of dietary factors to influence brain health are only now beginning to be recognized. Over the last decade, research has provided evidence that dietary components may influence mechanisms and molecular systems that maintain mental function, more specifically synaptic plasticity. Synapses or junctions, where virtually all important brain activity emerges, effectively control neuronal communication. Plasticity is the ability of the brain to adapt to new information; synaptic plasticity is the brain’s ability to strengthen or weaken the synaptic function as a result of learning. For example, repeating song lyrics strengthens the related connections in the brain that make it possible to easily recall the words.

A sharp mind and memory formation depend on the vitality of the brain’s network of interconnecting neurons. Research has established that synaptic activity, including synapse-specific modifications of synaptic strength, plays a vital role in learning and memory. The ability to learn and remember, as well as other mental and emotional processes, can be influenced by  factors such as stress, lack of stimulation or neurotoxins that may cause synapse dysfunction. A balanced diet, adequate amounts of physical activity, proper sleep, and healthy environmental interaction appear to have the potential to alter brain heath and mental function. Nutrients that influence cognition act on the necessary cellular processes for the maintenance of brain health. Encouraging results of clinical and preclinical studies raise the possibility that dietary interventions may be a viable strategy for enhancing cognitive abilities, protecting the brain from damage, promoting repair, and counteracting the effects of aging.

Adults of all ages looking to preserve brain heath and function throughout their lifespan, should consider following a healthy lifestyle to help protect and strengthen the synapses that keep minds active and alert. Lifestyle tips for healthy brain function include stress reduction and relaxation techniques, brain stimulation though demanding intellectual tasks, cardiovascular exercise to oxygenate the brain, adequate sleep, not smoking, taking alcohol in moderation and eating a nutritious diet that includes brain supportive nutrients. Per the National Institutes of Health (NIH), select nutrients have the capacity to affect neural pathways associated with synaptic plasticity that positively affects cognitive function. These dietary components have been identified as having effects on membrane fluidity, the regulation of neurotransmitter pathways, synaptic transmission and signal-transduction pathways.

DHA Omega-3 essential fatty acids, specifically DHA, are normal constituents of cell membranes and are essential for normal brain function. Dietary consumption of omega-3 fatty acids is one of the best-studied correlations between food and brain evolution. As the human body is not efficient at synthesizing DHA, we are largely dependent on dietary sources, such as oily fish, shellfish and algae. Dietary deficiency of omega-3 fatty acids has been associated with increased risk of mental health disorders, including dementia and depression. DHA may enhance cognitive abilities by facilitating synaptic plasticity, or through its positive effects on metabolism, glucose utilization, and mitochondrial function.

Turmeric/Curcumin – Studies suggest that curcumin has bioactive antioxidant, anti-inflammatory and neuro-protective effects. Population studies have shown that those who regularly consume curcuminoids as part of their traditional cuisine, such as in India and Asia, scored significantly better on cognitive function tests. Chronic low-grade inflammation plays a major role in many degenerative conditions. Curcumin’s strong anti-inflammatory properties may inhibit inflammation at the molecular level to help prevent or fight chronic inflammation. Curcumin may also boost levels of brain-derived neurotrophic factor (BDNF), which supports synaptic plasticity and cognitive function, as well as the survival of existing neurons and the differentiation of new neurons.

Flavonoids – Flavonoids, phytochemicals found in a variety of fruits and vegetables, have been identified as promising bioactive compounds capable of influencing certain aspects of brain function, including cerebrovascular blood flow, and synaptic plasticity and strengthening. Dietary flavonoids are believed to have the potential to protect against neurotoxin damage, suppress neuroinflammation, and promote memory, learning and cognitive function.

B vitamins – Per the NIH, B complex vitamins are absolutely essential for every aspect of brain function. These synergistic micronutrients work at a cellular level to support energy production, healthy mood and cognitive performance, as well as DNA/RNA synthesis and repair, and the synthesis of numerous neurochemicals and signaling molecules.

CoQ10/Ubiquinol – Found in virtually all cell membranes, CoQ10 (ubiquinone) is a powerful antioxidant and a vital participant in oxygen utilization and cellular energy production. By aiding energy production and protecting organ cells from oxidative stress and free radical damage, CoQ10 supports the overall health of all bodily cells, organs and tissues. Animal studies have shown that oral administration of CoQ10 can exert neuroprotective effects that may prove useful in the future treatment of neurodegenerative disease.

Professional Supplement Center carries these and other high quality supplements in support of brain and overall health:

ProDHA 1000 mg...ProDHA 1000 mg Strawberry by Nordic Naturals®: This high potency formula offers research- backed benefits for brain, eye, and nervous system health, as well as emotional wellbeing. Sourced from purified deep sea fish oil. Natural strawberry flavor. Naturally preserved with rosemary extract and d-alpha tocopherol. Gluten free, no artificial ingredients, Non-GMO verified.

Ubiquinol-QH 100 mgUbiquinol-QH 100 mg by Pure Encapsulations®: This product provides Kaneka QH™, a readily absorbable, active antioxidant form of CoQ10, in support of cellular energy production, cardiovascular health and free radical protection. Gluten free, hypoallergenic, Non-GMO formulation.

Curcumin 500 with...Curcumin 500 with Bioperine by Pure Encapsulations®: This product supplies 500 mg of turmeric standardized to contain 95% curcuminoids in support of a healthy inflammatory response, cellular health, and healthy liver, colon and musculoskeletal function. Bioperine® is added for enhanced bioavailability and absorption. Gluten free, hypoallergenic, Non-GMO vegan formulation.

FlavonALLFlavonAll by Douglas Laboratories®: This broad-spectrum flavonoid-based supplement delivers eight of the most concentrated and well-researched standardized plant extracts highly regarded for their beneficial antioxidant properties. Ingredients include Pycnogenol®, as well as grape seed, bilberry, and milk thistle extracts. Soy free, vegan formulation.

Active B-ComplexActive B-Complex by Integrative Therapeutics®: This product provides the full complement of bioavailable B vitamins in support of numerous biochemical processes and overall healthy function. Gluten, wheat, dairy, soy and artificial ingredient free, vegetarian formulation.

References:
Brain foods: the effects of nutrients on brain function. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805706/
Boost your memory by eating right. https://www.health.harvard.edu/mind-and-mood/boost-your-memory-by-eating-right
Nutrients for a Sharp Memory. http://www.todaysdietitian.com/newarchives/1217p24.shtml
4 Types of Foods to Help Boost Your Memory. https://www.eatright.org/health/wellness/healthy-aging/memory-boosting-foods
Do Memory Problems Always Mean Alzheimer’s Disease? https://www.nia.nih.gov/health/do-memory-problems-always-mean-alzheimers-disease
The synaptic plasticity and memory hypothesis: encoding, storage and persistence. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843897/
10 Proven Health Benefits of Turmeric and Curcumin. https://www.healthline.com/nutrition/top-10-evidence-based-health-benefits-of-turmeric
Flavonoids and brain health: multiple effects underpinned by common mechanisms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775888/
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21173/

 

Natural Non-Opioid Alternatives for Chronic Pain Management

NaturalPainManagementJacquie Eubanks RN BSN

Those who tuned in to the recent 60 Minutes investigative report on the opioid crisis no longer need to wonder what fueled America’s widespread ongoing drug epidemic. For many, it was shocking to learn that in April 2016, at the height of the deadliest drug epidemic in U.S. history, three major drug distribution corporations and the pharmaceutical industry successfully lobbied certain members of Congress to pass legislation that would maximize pharmaceutical profits at the expense of people’s lives. Under the guise of making pain medications available for those needing acute pain relief, the law allowed shipments of millions of opioids to continue unabated to shady pill mill operations, while unsuspecting or unscrupulous doctors handed out prescriptions like candy.

The industry-friendly legislation effectively made it relatively impossible for the Drug Enforcement Administration (DEA) to suspend a drug company’s operations when they failed to comply with federal law. The law weakened the DEA’s ability to freeze opioid sales to suspected pill mills, and allowed the pharmaceutical and drug distribution corporations to continue to deliver suspicious orders. Essentially the legislation sanctioned the pharmaceutical industry to unleash millions of highly addictive pharmaceutical grade prescription narcotics onto America’s streets. To make matters worse, dozens of qualified DEA agents, as well as Justice Department officials with intimate knowledge of DEA processes, are now employed by the pharmaceutical industry.

If a war on prescription painkillers actually exists, the drug industry is winning by raking in billions of dollars in profits.

Clearly, the American people are the losers. Although the current administration has yet to declare the opioid addiction crises a public health emergency, opioids have now claimed more than 200,000 American lives, and that shocking number continues to climb. Per the Centers for Disease Control and Prevention (CDC), 100 Americans tragically overdose every single day, either from prescription abuse or from the street heroin desperate people seek to feed the addiction resulting from legally or illicitly obtained prescription painkillers. Drug overdose is now the leading cause of accidental death, with over 52,000 lethal drug overdoses in 2015 alone. Nearly 92 million people, or 38% of the population used a legitimately prescribed opioid in 2015. In many cases, unused medication winds up in the hands of family members or friends. Surveys show that nearly 60% of opioid misuse involved taking opioids without a prescription.

Many blame Big Pharma for sowing the seeds of addiction by downplaying the addictive nature of the drugs in a way that was later shown to be false and misleading. Aggressive marketing to physicians along with lucrative awards for prescribing the controlled substances helped to make opioids widely available. Per the National Institutes of Health, opioid tolerance, dependence and addiction are all manifestations of brain changes resulting from chronic abuse. When opioids travel through the bloodstream to the brain, the chemicals attach to specialized proteins or opioid receptors of opioid sensitive brain neurons, triggering the brain’s pleasure reward systems. While opioids are prescribed therapeutically to relieve pain, in the absence of pain they motivate repeated use of the drug simply for pleasure. Compulsion builds over time and leads to brain cravings, driving abusers to seek out more drugs despite numerable obstacles. Repeated exposure to escalating dosages alters the brain so that it functions normally only when drugs are present. As tolerance builds and higher doses are needed to produce the same pleasurable feeling, drug dependence susceptible to withdrawal symptoms and overdoses ensues.

While these highly addictive pain medications should be available for those who need short term relief, those with long term needs for chronic pain relief may consider safer alternatives to prescription pain medications.

Boswellia-Turmeric...Boswellia-Turmeric Complex by Douglas Laboratories®: This synergistic blend of three standardized botanical extracts work to support the body’s natural physiological responses, protect the body’s connective tissues, provide oxidative damage protection, and strengthen the body’s natural anti-inflammatory response. Soy free, vegetarian formulation.

 

Curcumin 500 with...Curcumin 500 with Bioperine® by Pure Encapsulations®: This highly bioavailable complex supports the body’s natural inflammatory response, promotes natural detoxification, and helps maintain healthy liver, colon, musculoskeletal, and cellular functions. Gluten and soy free, Non-GMO vegetarian formulation.

 

Advanced...Advanced Inflammation Support by Complementary Prescriptions: This comprehensive botanical formulation includes multi-modal ingredients and adaptogens to aid maintenance of a balanced inflammatory response.

 

Ultra Omega 900Ultra Omega 900™ by Neurobiologix: This highly concentrated, ultra-pure formula provides enteric coated essential fatty acids sourced from arctic Alaskan waters. Molecularly distilled, independently tested for toxins and stabilized with vitamin E, Ultra Omega supports brain, joint eye, cardiovascular, gastrointestinal and overall health. Recommended amounts of EPA and DHA have been shown to benefit joint inflammation, and nervous system function, as well as pain relief. Wheat, gluten, yeast, dairy, preservative and artificial ingredient free.

 

RevitalAge Nerve ...RevitalAge™ Nerve by Pure Encapsulations®: This scientifically researched complex provides support for peripheral neuronal function and comfort. Targeted ingredients support mitochondrial function, cellular energy production, and antioxidant protection. Gluten free, Non-GMO vegetarian formulation.

 

SAMe 400 mgSAMe 400 mg by Source Naturals®: These stable, bioavailable enteric coated tablets support joint comfort, function and mobility in the spine, hips, and knees. Present in every living cell, SAMe plays a role in many critical functions and helps to support a positive outlook. Gluten, yeast, dairy, egg, gluten, soy, wheat, preservatives, and artificial ingredient free.

 

Phyto UltraComfort ...Phyto UltraComfort by Pure Encapsulations®: This product supplies traditional botanicals known to reduce occasional minor pain and helps to maintain a healthy inflammatory response by supporting healthy enzyme and immune mediator activities. Gluten and soy free, Non-GMO vegetarian formulation.

References:
Short Answers to Hard Questions About the Opioid Crisis. https://www.nytimes.com/interactive/2017/08/03/upshot/opioid-drug-overdose-epidemic.html
Drug overdose deaths in the United States continue to increase in 2015. https://www.cdc.gov/drugoverdose/epidemic/index.html
Behind the Curtain of the Opioid Epidemic: The Companies That Profit. http://www.narconon.org/blog/behind-the-curtain-of-the-opioid-epidemic-the-companies-that-profit.html
More than 1 in 3 Americans prescribed opioids in 2015. https://www.cbsnews.com/news/more-than-one-third-americans-prescribed-opioids-in-2015/
Opioid Addiction 2016 Facts & Figures. https://www.asam.org/docs/default-source/advocacy/opioid-addiction-disease-facts-figures.pdf
The Neurobiology of Opioid Dependence: Implications for Treatment. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851054/
The Drug Industry’s Triumph Over The DEA. https://www.washingtonpost.com/graphics/2017/investigations/dea-drug-industry-congress/?utm_term=.d6915eff5fd7
Opioid Crisis. https://www.drugabuse.gov/drugs-abuse/opioids/opioid-crisis
Understanding the Epidemic. https://www.cdc.gov/drugoverdose/epidemic/index.html