Tag Archives: GABA 750 mg by Integrative Therapeutics

Neurotransmitters – The Great Communicators

NeurotransmittersJacquie Eubanks RN BSN

Neurons are specialized nerve cells that receive, process and convey information to other neurons and bodily cells. These information messengers use electrical impulses and chemical signals to transmit, boost and balance information between different areas of the brain, as well as between the brain and the rest of the nervous system. Nerve cells produce enzymes that synthesize most neurotransmitters, signaling chemicals that affect a wide variety of physical and psychological functions. Without the work of neurons and their support cells, the human body could not thrive in homeostasis. In fact, our brains rely on the smooth, fast and efficient release of neurotransmitters to regulate heart rate, sleep, appetite, and mood, as well as enable breathing, learning, reasoning, memorizing, concentration and movement.

Generally neurons do not touch one another and instead communicate by releasing neurotransmitters across a tiny gap, or synapse, transmitting signals that either stimulate (excite) or inhibit (calm) the receiving cells. A neuron can simultaneously receive many impulses, both excitatory and inhibitory from other neurons. Known as summation, a receiving neuron compiles or consolidates multiple signals, firing and calling other neurons into action when more excitatory signals are received. If the sum of the signals is inhibitory, the neuron does not fire and does not influence the activity of other neurons.

Malfunction of these processes has been linked to neurodegenerative diseases such as Alzheimer’s, Huntington’s and Parkinson’s; gastrointestinal disorders, including diverticulitis, irritable bowel, Crohn’s and celiac disease; and disorders such as anxiety, depression, epilepsy and autism. Some of the more well known neurotransmitters are:

GABA: The brain’s main inhibitory chemical messenger, GABA contributes to vision and motor control and plays a major role in reducing neuron excitability and anxiety regulation, as well as relaxation and calmness.

Glutamate: The most plentiful excitatory neurotransmitter found in the nervous system, glutamate plays a role cognition, memory and learning and helps to balance the effects of GABA.

Glycine: The main inhibitory neurotransmitter of the spinal cord, glycine is vital for maintaining healthy central nervous and digestive system functions, as well as the synthesis of nucleic acids. It may also inhibit neurotransmitters linked to seizures and hyperactivity.

Endorphins: Produced naturally by the body, endorphins inhibit the transmission of pain signals and promote pleasurable feelings. Endorphin production can be triggered by physical activities, such as aerobic exercise.

Epinephrine: Better known as adrenaline, epinephrine functions as a neurotransmitter in the brain and as a stress hormone released by the adrenal glands.

Norepinephrine: This neurotransmitter plays a major role in the body’s fight or flight response, boosting alertness and mobilizing the body and brain to act during times of stress, fear or danger.

Histamine: Produced as part of the immune system’s response to pathogens, histamine plays a role in allergic reactions and the inflammatory response.

Dopamine: Dopamine is involved in reward and motivation and plays an important role in body movement coordination.

Serotonin: Serotonin helps to regulate and modulate mood, sleep, anxiety, sexuality and appetite, and helps to balance excessive excitatory neurotransmitter effects in the brain.

Adenosine: This brain neuromodulator is involved in cellular energy transfer, signal transduction and the synthesis of RNA. As an inhibitory neurotransmitter, adenosine can act as a central nervous system depressant, promoting sleep and suppressing arousal.

Adenosine triphosphate (ATP): Present in all living tissue, ATP provides energy for physiological processes, including muscle contraction, chemical synthesis and nerve impulse transmission.

Nitric oxide: Nitric oxide relaxes smooth muscles, allowing for blood vessel dilation and increased blood flow.

Carbon monoxide: Generally known for its toxic effects when exposed to high levels, carbon monoxide produced naturally by the body acts to modulate the body’s inflammatory response.

Acetylcholine: Found in both the central and peripheral nervous systems, acetylcholine is the primary neurotransmitter associated with motor neurons and muscle movements. It plays a role in memory, learning and sleep as well.

Professional Supplement Center offers many high quality formulations in support of overall health and function:

Gaba 750 mgGABA 750 mg by Integrative Therapeutics®: One capsule provides 750 mg of GABA in support of healthy brain cell function and neurochemical balance. Free of sugar, salt, yeast, wheat, gluten, corn, soy, dairy and artificial colors, flavors and preservatives. Vegetarian formulation.

 

Calm GCalm G by NeuroScience™: Calm G provides a blend of vitamins, minerals, amino acids, CoQ10 and other nutrients important for the regulation of glutamate activity, stress reduction, metabolic health and mitochondrial function.

 

Glycine 500 mgGlycine 500 mg by Douglas Laboratories®: This amino acid formula supports glutathione and nucleic acid synthesis, as well as bile production. Glycine may also support neurological, gastrointestinal and connective tissue health. Free of yeast, wheat, gluten, soy protein, dairy, corn, sodium, sugar, starch and artificial coloring, preservatives and flavoring.

 

SeratoninSeratonin™ by Allergy Research Group: This patented formula is designed to support neurotransmitters involved in healthy mood, sound sleep and a balanced stress response.

 

DopaPlusDopaPlus by Pure Encapsulations®: This hypoallergenic formula provides neurotransmitter precursors to boost, balance and promote dopamine production in support of enhanced daily mental function, emotional wellness and positive mood. Gluten free, Non-GMO formulation.

 

D-Ribose with Peak...D-Ribose with Peak ATP® by Progressive Laboratories®: D-ribose is a critically important sugar molecule and essential component of ATP, the source of cellular energy. Peak ATP®, developed through a proprietary fermentation process, delivers the exact molecule the body needs to create energy.

 

Nitric Oxide Ultra...Nitric Oxide Ultra Stick Packs by Pure Encapsulations®: This great tasting powdered formula combines clinically researched ingredients for enhanced nitric oxide production, healthy blood flow and vascular health. Hypoallergenic, gluten free, Non-GMO formulation.

 

References:
Neurotransmission. https://www.merckmanuals.com/professional/neurologic-disorders/neurotransmission/neurotransmission
Neurotransmitters: How Brain Cells Use Chemicals to Communicate. https://www.brainfacts.org/archives/2011/neurotransmitters-how-brain-cells-use-chemicals-to-communicate
Neurotransmitters. https://allpsych.com/psychology101/neurotransmitters/
Neurotransmitters: The critical modulators regulating gut-brain axis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772764/
Identifying a Neurotransmitter. https://www.verywellmind.com/what-is-a-neurotransmitter-2795394
Neurotransmitter and receptors. https://www.khanacademy.org/science/biology/human-biology/neuron-nervous-system/a/neurotransmitters-their-receptors

Anxiety

AnxietyJacquie Eubanks RN BSNAnyone who has experienced anxiety is familiar with what can be described as an unpleasant feeling, a vague sense of unease and apprehension. While anxiety disorders affect over 40 million adults in the US, virtually everyone has felt anxious at some point in time. Symptoms such as mild stomach discomfort, perspiration, a quickening of the heartbeat, are common reactions to stressful situations. Similar to fear, anxiety triggers the fight or flight stress response and the release of stress hormones, including adrenaline, to see you through a momentary anxiety producing circumstance.

Normal intermittent anxiety is beneficial in certain temporary situations, a job interview, a college exam, public speaking, or what a performer would call opening night jitters. When anxiety becomes chronic or irrational and begins to interfere with normal everyday life, it can lead to physical illness and a psychological disorder diagnosis. Dissimilar to fear, which is a rational response to a real danger, chronic irrational anxiety generally lacks a clear or realistic cause, yet still produces physical responses that can become debilitating and lead to chronic conditions.

Chronic disproportionate anxiety that negatively affects sleep and concentration or results in avoidance of social situations, is classified as a disorder. While treatable, statistics show that a large percentage of adults who have anxiety disorders never receive treatment, such as therapy or medications. People who have undiagnosed or untreated anxiety disorders are more likely to self-medicate with nicotine, alcohol or street drugs that may temporarily relieve anxiety symptoms, but may also greatly affect general health and wellbeing in the long term. Those who are struggling to manage the symptoms of persistent, but not debilitating, anxiety may have anxious thoughts or behaviors that may be improved by dietary and lifestyle changes.

  • Eating more protein and healthy fats, not skipping meals, and avoiding sugar and refined carbs can keep blood sugar stable and eliminate blood sugar crashes. Low blood sugar can initiate a stress response and the release of stress hormones that feels eerily like anxiety.
  • Gradually decreasing caffeine intake until you can eliminate it entirely can help to improve sleep, stabilize energy and improve the stress response.
  • Getting adequate, restful sleep helps to eliminate the anxiety-insomnia-sleep deprivation cycle, leaving one less vulnerable to anxiety. To help wind down in the evening, dim the lights an hour before bedtime, take a warm shower or bath, or do a short meditation and some gentle stretching to help you relax.
  • Taking probiotics and eating fermented foods can help to promote healthy gut flora and improve gastrointestinal function. Digestive tract health can affect mood and may play a role in anxiety disorders.
  • Take every opportunity to get in some physical activity, as exercise helps to relieve stress and anxiety.

Anyone who struggles with anxiety will tell you that managing anxiety is not an easy task. Good lifestyle habits are certainly beneficial, as proper diet, sufficient exercise, and good quality sleep can noticeably improve the anxiety and stress response. As well, proper supplementation can improve the quality of sleep, provide calming minerals, support mood and neurotransmitter production and aid adrenal function, resulting in anxiety relief, improved focus, increased energy and more optimal stress management.

L-theanine – Found naturally in green tea, this amino acid enhances cognition and focus, while surprisingly promoting relaxation without inducing drowsiness. Utilized to naturally relieve anxiety and stress, L-theanine calms both the body and the mind, bringing about a state of wakeful relaxation. When you need to chill out, L-theanine can help.

Magnesium – Widely known as a calming mineral, magnesium is involved in hundreds of biochemical processes, including energy production, blood glucose regulation and stress management, as well as immune system and adrenal function support. Magnesium deficiency is linked to symptoms of anxiety, depression, mood imbalances, and insomnia, all of which benefit from magnesium repletion.

GABA – Synthesized naturally in the brain and widely distributed throughout the central nervous system, GABA is a major neurotransmitter that has relaxation-inducing and stress-relieving effects. Low levels are GABA are associated with anxiety, depression and insomnia. Clinical studies have shown that GABA supplementation can promote feelings of calmness, increase metal clarity and focus, and support more restful sleep.

Kava – Used traditionally for centuries to enhance relaxation, improve mood and support sleep, kava has been shown to elevate mood, improve stress management, reduce the negative effects of stress, and relieve symptoms associated with generalized anxiety, including persistent worry, restlessness, insomnia, fatigue and muscle tension.

Professional Supplement Center carries these and other high quality formulas to support overall health and a healthy stress response:

L-Theaninel-Theanine by Pure Encapsulations: One capsule provides 200 mg of l-theanine as Suntheanine®, a unique amino acid that provides helpful relaxation support, and eases occasional nervous tension and irritability with causing drowsiness. Gluten and soy free, Non-GMO vegetarian formulation.

Magnesium (glycinate...Magnesium Glycinate by Pure Encapsulations: Magnesium supports the metabolism and utilization of nutrients and the proper functioning of critical enzymatic and physiological functions. Important for muscle function and mood balance, magnesium in glycinate form is less likely to cause bowel discomfort than other forms of magnesium. Gluten and soy free, Non-GMO vegetarian formulation.

Gaba 750 mgGABA 750 mg by Integrative Therapeutics: One capsule provides 750 mg of GABA in support of the neuroendocrine system. This pure vegetarian formula is gluten, soy, dairy and sugar free.

 

Kava (Formerly...Kava by Herb Pharm: This liquid extract is sourced from sustainably harvested Kava grown in the Vanuatu Islands in the South Pacific according to ancient agricultural traditions. Kava provides nervous system support, promoting peaceful relaxation and stress reduction. This formula is prepared from the whole rhizome and root and is extracted with pharmaceutical grade certified organic grain alcohol. Gluten free, Non-GMO formulation.

Kava KavaKava Kava by Professional Solutions: Formulated with ecologically harvested Kava Kava from Vanuatu, this potent herbal extract supports calm, relaxation and bodily systems negatively affected by stress. Vegetarian formula. Contains Non-GMO soy.

 

References:
What is Anxiety? https://www.anxiety.org/what-is-anxiety
Understanding the Anxious Mind. http://www.nytimes.com/2009/10/04/magazine/04anxiety-t.html
Magnesium and the Brain: The Original Chill Pill.  https://www.psychologytoday.com/blog/evolutionary-psychiatry/201106/magnesium-and-the-brain-the-original-chill-pill
Murray, Michael, M.D. Easing the Agony of Anxiety & Panic Attacks. Vitamin Retailer, February 2017
Is It Normal Anxiety or an Anxiety Disorder? https://www.verywell.com/is-it-normal-anxiety-or-an-anxiety-disorder-2584401

Let’s Talk Neurotransmitters

NeurotransmittersJacquie Eubanks RN BSN

 

 

Neurotransmitters are chemical messengers that allow signals to cross synapses to transmit information from a nerve cell or neuron to a target cell. Essentially, a synapse is the junction point between two neurons. As the basic working unit of the brain, neurons are specialized cells within the nervous system that allow the brain to transmit electrically charged messages to other nerve, gland and muscle cells. Because neurotransmitters relay information that causes reactions, such as telling a muscle to contract or a gland to secrete a hormone, anything that affects the behavior of neurotransmitters affects the function of the body. By their effects on neurotransmitter receptor cells, neurotransmitters coordinate behavior by stimulating an action or inhibiting an impulse.

Scientists have identified at least 100 neurotransmitters, and evidence suggests we may have a significantly higher amount. Many neurotransmitters are synthesized from precursors like amino acids. Each one performs specific tasks and plays a major role in everyday life and function. To be identified as a neurotransmitter, a chemical must be synthesized in a neuron, must be released and produce a targeted response and must have a mechanism to remove the chemical from the activation site once it has finished its intended function. Neurotransmitters are commonly described as either inhibitory or excitatory.

Neurotransmitter imbalances are connected to diseases and health conditions, including Parkinson’s, depression, insomnia, anxiety, cravings, ADHD, memory loss, fatigue, low libido, weight problems and addictions. Aging, chronic stress, nutritional deficiencies, environmental toxins and alcohol and drug abuse are believed to be primary contributors to neurotransmitter imbalances. Many medications are designed to address symptoms of illness by effectively targeting and altering neurotransmitter activity. The identification and function of neurotransmitters remains an open field of scientific study. However, we do now know that a single neuron can produce several different neurotransmitters.

Some of the more familiar identified neurotransmitters include:

Dopamine – Dopamine functions as both an inhibitory and excitatory neurotransmitter and is critical for memory and motor skills. Dopamine plays a role in behavior, learning, sleep, mood, focus, attention, immune health and pleasurable reward. Pleasurable situations, such as eating and sexual activity, stimulate the release of dopamine. Abnormal dopamine levels are associated with attention deficit, exhaustion, Parkinson’s disease and Obsessive Compulsive Disorder (OCD). Certain addictive drugs, such as cocaine and amphetamines, inhibit the re-uptake of dopamine, increasing the amount of dopamine in the reward centers. Stimulants, such as prescription medications that address symptoms of ADD and ADHD, temporarily address symptoms of low dopamine.

GABA – As the major inhibitory neurotransmitter widely distributed in the brain, GABA is considered a significant mood modulator. When GABA levels are too low or GABA action is impaired, neurons can become overexcited, which can lead to restlessness, anxiety and irritability. The natural function of GABA is to reduce any overactivity or over-excitability of neurons throughout the nervous system, promoting calmness and relaxation and decreasing brain activity. GABA aids neurons in recovery after firing, helping to reduce anxiety and worry. Pharmaceuticals that enhance GABA action are used to treat anxiety, seizures, restless sleep and other neurological or psychological disorders.

Glutamate – The most common neurotransmitter in the central nervous system, glutamate is an excitatory relative of GABA that is involved in most aspects of brain functioning, including cognition, learning and memory. Glutamate is considered a major mediator of excitatory signals, regulating brain development as well as the elimination and formation of nerve synapses. Glutamate is located within the cells, where it remains relatively inactive until needed. It is released in highly controlled amounts and is quickly taken back into the neuron once the message has been delivered. High levels of glutamate are actually toxic and can inflict massive neuron damage if spilled into brain tissue, such as when caused by a stroke or traumatic brain injury.

Serotonin – Present in the brain and digestive tract, inhibitory neurotransmitter Serotonin has been identified as an important factor in mood, depression, anxiety, sleep quality, emotions and the regulation of appetite and body temperature. Serotonin imbalances are involved in depression, impulsive behavior, sleep and emotional disorders, increased appetite and aggressiveness. Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications that ease symptoms of depression and anxiety. Pharmaceuticals that help people with depression work by preventing neurons from mopping up excess serotonin.

Acetylcholine (ACh) – This widely distributed excitatory neurotransmitter was the first neurotransmitter to be identified. ACh triggers voluntary muscle contraction, controls the heartbeat and stimulates the excretion of certain hormones. Research suggests that ACh may be critical for sleep, attentiveness, sexuality and memory. Alzheimer’s disease is associated with a lack of ACh in certain brain regions. Medications that increase ACh in the brain are the primary drugs used to treat Alzheimer’s disease.

Video Let's Talk Neurotransmitters

Norepinephrine – Also known as nor-adrenaline and widely distributed throughout the body, norepinephrine acts as a neuromodulator, optimizing brain performance. As part of the body’s fight or flight response, norepinephrine quickly provides an accurate assessment of danger or stressful situations. Excessive amounts of this chemical, especially when no actual danger exists, can leave you anxious and hyperactive, while moderately low amounts have beneficial effects on sleep, concentration, inflammation and stress resilience.

Epinephrine – Widely known as adrenaline, epinephrine is both a neurotransmitter and a hormone that is essential to metabolism, attention, mental focus and our innate response to stress, fear, anger, panic or excitement. Synthesized from norepinephrine and released by the adrenal glands, epinephrine results in a state of hyperawareness followed by an energy surge that quickens the heartbeat, strengthens the force of the heart’s contraction and opens air passages in the lungs. Abnormal levels of epinephrine are linked to sleep disorders, anxiety, hypertension and lowered immunity.

The importance of neurotransmitters cannot be understated. Neurotransmitters control our wondrous and highly complicated human body, including our thought patterns, senses, moods, breathing, heart rate, appetite, digestion, voluntary and involuntary movement, reflexes, hormones, emotions, desires, memories, obsessions and personality. Nutritional support for neurotransmitter synthesis includes amino acids, fundamental building blocks of neurotransmitter production. Turmeric, glutathione, NAC, selenium and magnesium all support neurotransmitter activity. In addition, 30 minutes of daily exercise is believed to boost brain serotonin levels.

NAC 600 mgNAC 600 mg by Pure Encapsulations – This free-form amino acid combined with vitamin C provides powerful antioxidant support. As a precursor to glutathione, NAC aids in support of healthy lung function and helps maintain a healthy immune response. Gluten free, Non-GMO vegetarian formula.

 

Liposomal Glutathione (HEAT SENSITIVE PRODUCT)Liposomal Glutathione by Empirical Labs – Scientifically studied liposomal technology allows for the use of non-hydrogenated phosphatidylcholine as a delivery system for glutathione. Each serving provides 500 mg of reduced glutathione along with 400 mg of natural phosphatidylcholine for optimal absorption, maximum nutrition and potent antioxidant protection. Non-GMO formulation.

 

Turmeric Max-V 100 mg (77377)Turmeric Max-V 100 mg by Douglas Laboratories – Turmeric’s powerful antioxidant properties are believed to play a role in supporting neurological and cardiovascular function. Traditionally used in Ayurvedic medicine to support ocular and gastrointestinal function, one capsule supplies 100 mg of turmeric herbal extract standardized to 95% curcuminoids. Soy free, vegan formula.

 

Gaba 750 mgGABA 750 mg by Integrative Therapeutics – Produced naturally in the brain, this amino acid aids in the production of inhibitory neurotransmitters, calming overexcited nerve impulses, reducing anxiety and aiding relaxation. Gluten, lactose and soy free, vegetarian formula.

 

References:
The Neuron. http://www.brainfacts.org/brain-basics/neuroanatomy/articles/2012/the-neuron/
Neurotransmitter – Function and Characteristics. http://science.jrank.org/pages/4624/Neurotransmitter.html
Selective serotonin reuptake inhibitors (SSRI’s). http://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825
Dopamine Functions. http://www.news-medical.net/health/Dopamine-Functions.aspx
The Neurotransporter Group. http://neurotransporter.org/glutamate.html
Protecting the Brain from a Glutamate Storm. http://www.dana.org/Cerebrum/2007/Protecting_the_Brain_from_a_Glutamate_Storm/
Effects of Nutrients on Neurotransmitter Release. http://www.ncbi.nlm.nih.gov/books/NBK209058/