Tag Archives: Kavinace

The Phenibut Controversy & Kavinace

PhenibutSusan Brown Health and Wellness Editor

In April of 2019, The U.S. Food and Drug Administration (FDA) issued warning letters relating to the use of phenibut in dietary supplements. The letters did not include any allegations regarding promotional claims or violations of good manufacturing practices. This action prompted many popular products, including Kavinace by NeuroScience, to reformulate their products in order to comply.

The agency alleged that the mere presence of phenibut in a supplement renders it unlawful, as phenibut does not meet the statutory definition of a dietary ingredient under the Federal Food, Drug and Cosmetic Act (FD&C) that regulates dietary supplements. The FD&C Act defines a dietary supplement as “a vitamin; mineral; herb or other botanical; amino acid; dietary substance for use by man to supplement the diet by increasing total dietary intake; or a concentrate, metabolite, constituent, extract or combination of preceding substances.”

Per the FDA, the Dietary Supplement Ingredient Advisory List is an integral part of the FDA’s overall effort to strengthen the agency’s regulation and oversight of dietary supplements to meet the demands of the growing supplement industry. ”Because phenibut does not fit any of the categories of dietary ingredients under the FD&C Act, any dietary supplements that declare phenibut as a dietary ingredient are misbranded.”

Sometimes referred to as a “smart drug,” phenibut appears to have mood and cognitive enhancing effects and the potential to improve productivity and focus due to its ability to cross the blood brain barrier. Until recently phenibut was utilized as a dietary supplement ingredient, largely for its calming, relaxing effects, as well as for improved concentration and attentiveness.

Initially developed by Russian chemists in the 1960’s, phenibut was primarily utilized by cosmonauts during space flights to combat anxiety and insomnia. Similar in structure to the inhibitory neurotransmitter GABA, which plays a role in reducing excitability and anxiety, phenibut stimulates dopamine receptors and binds to GABA receptors, where it activates similar reactions.

Phenibut is a licensed medication in Russia, where it is widely used for a variety of conditions, including insomnia, anxiety and tension relief, and is utilized as a therapeutic agent for depression, alcohol withdrawal syndrome and post-traumatic stress disorder.

Inclusion on the advisory list is not necessarily an indication of safety concerns. It means that phenibut does not meet the current agency standards and therefore cannot legally be marketed as a dietary supplement or ingredient. This does not mean that the FDA’s position is indisputable as the definition of “increased dietary intake” remains open to debate.

Sleep Balance HerbalSleep Balance Herbal by Diamond Formulations has been formulated to comply with FDA regulations. Sleep Balance Herbal provides well researched therapeutic ingredients known to support calming neurotransmitter production to improve sleep quality, promote sleep onset and encourage healthy restorative sleep. These specific nutrients contribute to feelings of calmness and relaxation, as well as support a healthy positive outlook and a general sense of wellbeing. Free of wheat, yeast, soy, gluten, dairy, animal products, fish, shellfish, peanuts, tree nuts, eggs and artificial colors, sweeteners and artificial preservatives. Non-GMO, Kosher formulation.

FDA Acts of Dietary Supplements Containing DMHA and Phenibut. https://www.fda.gov/food/cfsan-constituent-updates/fda-acts-dietary-supplements-containing-dmha-and-phenibut
Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug. https://www.ncbi.nlm.nih.gov/pubmed/11830761
FDA Announces Actions Against Phenibut and DMHA Dietary Supplements.  https://www.venable.com/insights/publications/2019/04/fda-announces-actions-against-phenibut-and

NeuroScience – Featured Brand

neuroscienceSusan Brown Health and Wellness Editor



For nearly two decades, NeuroScience™ has offered proprietary holistic formulations designed to address neurological, hormonal and chemical imbalances. Today, NeuroScience™ is recognized as a highly-respected pioneer in the development of innovative premium nutraceuticals. These professional-grade formulas provide balanced support for healthy nervous, immune and endocrine system function.

NeuroScience™ researches clinical studies and peer-reviewed scientific journals to develop safe, efficacious products that provide impactful amounts of synergistic ingredients in a practical daily serving. Their formulations provide proprietary blends of amino acids, botanicals, vitamins, and minerals to address the root causes of health challenges to help individuals achieve more optimal heath.

Available solely through healthcare professionals, NeuroScience™ products are manufactured in a rigorously regulated FDA-inspected facility following strict cGMP practices. Impartial third-party testing assures verified label ingredients, as well as the absence of heavy metals and microcontaminants.

To see the full line of products from NeuroScience™, please visit professionalsupplementcenter.com

SereneSerene: This amino acid formulation provides ingredients to support optimal serotonin synthesis important for healthy sleep and positive mood. Serotonin is the precursor to naturally produced melatonin, a hormone that regulates sleep/wake cycles. Serene is designed to help decrease occasional anxiousness, support healthy mood, and promote relaxation.  Ingredients include calcium, folate, vitamins C and B6 and the amino acid, 5-HTP.

ExcitaPlus®ExcitaPlus: This non-glandular product is formulated with specific amino acids, vitamins, minerals and rhodiola in support of healthy cortisol, dopamine, epinephrine and norepinephrine synthesis. ExcitaPlus is designed to help reduce stress-induced fatigue and provide support for adrenal health and energy production, as well as cognition and focus.

TravaCorTravaCor: This unique combination of amino acids along with vitamin and mineral cofactors provides support for the calming neurotransmitter system. These widely studied nutrients have been shown to have the ability to reduce stress, support a healthy mood, produce a calming effect, reduce irritability and restlessness, and aid healthy restful sleep.

KavinaceKavinace®: This top selling, well-respected formula naturally calms, and promotes healthy levels of GABA, thereby reducing symptoms of insomnia and anxiety. Useful for stress relief and restful sleep, Kavinace® supports GABA’s natural ability to control overactive neurons that can cause restlessness and negatively impact healthy sleep. The formula includes a proprietary amino acid blend, and vitamin B6, an important cofactor in GABA synthesis.

Featured Brand – NeuroScience™

neuroscienceSusanBiconBy Susan Brown
Health & Wellness Editor

NeuroScience™ has a mission to better understand each person’s unique biochemistry and aims to improve quality of life through better science and neuro-immune based medical dietary supplements. NeuroScience™ offers proprietary nutraceuticals designed to deliver personalized health care solutions by targeting neurological and hormonal imbalances. In order to achieve optimal health, NeuroScience™ develops innovative and balanced healthcare solutions with the appreciation that the nervous, endocrine and immune systems must communicate and work synergistically to address the root causes of chronic illness.

Neuroscience Video

NeuroScience™ believes the function of the central nervous system, including a balance of neurotransmitters, plays an essential and fundamental role in the health of all bodily systems and improved patient outcomes. Their advanced, science-based nutraceuticals are designed to address chemical imbalances and provide effective interventions for inflammatory disorders. NeuroScience™ products are available solely through health care professionals.

The following are some of our best selling customer favorite products from NeuroScience:

Kavinace®Kavinace® – This very popular and well respected formula naturally calms and promotes healthy levels of GABA, thereby reducing symptoms of insomnia and anxiety. Kavinace is useful for stress relief and restful sleep and increases GABA’s natural ability to control overactive neurons that can cause anxiety. The formula includes vitamin B6, an important cofactor in GABA synthesis. Gluten and soy free, vegetarian formula. Kavinace Ultra PM formula also available.

AdreCor®AdreCor® – Formulated to support healthy adrenal function and aid adrenal hormone synthesis of epinephrine (adrenaline), norepinephrine and cortisol, Adrecor® helps to maintain energy levels and aids in stress management. Gluten and soy free, vegetarian proprietary formula.


Balance D®Balance D® – This product supplies key ingredients that support the production of dopamine as well as epinephrine, norepinephrine and glutathione. Balance D® aids in craving control, enhances memory, motor control and movement, and supports the brain’s natural reward system. Gluten and soy free, vegetarian formula.

ImmuWell – This formula supports the chemical messengers that maintain balance between the nervous and immune systems to promote a positive mood and healthy stress and immune responses. Gluten and soy free formula.


Should you have any questions about these or any other products, please call or email Professional Supplement Center. We are always happy to assist you.