Tag Archives: Melatonin PR 3 mg Prolonged Release by Douglas Laboratories

Sleep, There’s a Time for Everything

Healthy sleepJacquie Eubanks RN BSN

Many of us may think of our circadian rhythms only in relation to the ever important sleep/wake cycle. While it is known that this cycle is directly influenced by light and darkness, circadian rhythms are innate timing devices guided by biological processes within all bodily cells. These rhythms are 24-hour physiological patterns that most organisms follow each day. Just as the moon influences the tides, and the sun generates photosynthesis in plants, the human body’s integral biological clocks produce circadian rhythms that regulate the timing and govern the behavior of hormone levels, body temperature, metabolism and of course, sleep.

Located in a region of the hypothalamus, the body’s master clock, or suprachiasmatic nucleus (SCN) comprises thousands of cells that control behavioral rhythm. Tasked with coordinating all the biological clocks to maintain balance or homeostasis, the SCN receives information directly from the eyes’ optic nerves, which is why light and darkness are central to the regulation of melatonin production. When there is less light, such as after sunset, the SCN directs the pineal gland within the brain to decrease body temperature and increase production of melatonin, the hormone that brings on drowsiness to prepare the body for sleep. Melatonin levels peak in the middle of the night and gradually decrease by morning, as the body begins to prepare for waking and activity.

There are many factors that can interfere with the sleep/wake cycle, including natural aging, stress, medications, sleep environment, food and drinks, as well as genes that control the excitability of neurons or influence the circadian rhythms and timing of sleep. Perhaps the greatest negative influence on sleep patterns is exposure to artificial light at night from smart phones, computers, televisions and light bulbs, which suppress the production of melatonin more than natural daylight. As melatonin levels begin to rise several hours before bedtime, creating optimal conditions such as turning off devices and keeping the lights low for two hours before retiring for the night, as well as getting some daytime exposure to sunlight will help to assist melatonin production.

Insomnia, occasional sleeplessness or interrupted sleep are common conditions in today’s high-stress world. As a natural hormone and powerful antioxidant, therapeutic use of melatonin for occasional sleepless nights is widely acknowledged to safely induce restful sleep. As well, taking small to moderate doses of melatonin does not appear to reduce the body’s own natural production of melatonin. Melatonin that is manufactured synthetically or extracted from plants is chemically identical to the melatonin produced by the body. For difficulty falling asleep melatonin should be taken thirty to sixty minutes before bedtime. For night owls wishing to get to sleep earlier, take melatonin two hours before desired bedtime. For those who have trouble staying asleep, a time-release formula may be best. Experts suggest starting with the lowest possible effective dose to improve sleep.

Melatonin is nonhabit-forming and is considered quite safe. Short-term use of melatonin is well tolerated and does not appear to cause adverse effects. Research suggests that very low dose melatonin may be applicable for jet lag, delayed sleep, and sleep problems related to shift work and circadian rhythm disorders. While a complex and necessary process, the need for sleep is still largely undetermined. We do know however, that quality sleep at the right time is as essential to healthy function as nourishment is to survival. Sleep affects most bodily systems including the cardiovascular, respiratory and immune systems. Scientists have implicated a lack of sleep, as well as the consequent disruption of circadian rhythms, in the development of obesity, depression, diabetes and other chronic diseases.

Scientific research shows that melatonin supplements may help to strengthen and improve sleep/wake cycles, making it possible to adhere to more healthful sleep patterns. The maintenance of consistent healthy circadian rhythms improves daily physiological and psychological function and provides long-term benefits for health span as well as lifespan.

Professional Supplement Center offers high quality products to support safe restful sleep: 

Sleep BalanceSleep Balance by Diamond Formulations: Sleep Balance is formulated to promote and maintain restful sleep. Specific ingredients encourage normal, healthy restorative sleep, as well as discourage sleep disruption. Free of wheat, yeast, soy, gluten, animal and dairy products, fish, shellfish, peanuts, tree nuts, eggs, artificial colors, artificial sweeteners and artificial preservatives. Non-GMO kosher formulation.

Melatonin 3 mgMelatonin 3 mg by Vital Nutrients: Melatonin 3 mg supports the onset of sleep, balanced sleep/wake cycles and better quality more restful sleep in support of mental, physical and emotional health. Free of gluten, wheat, daily, soy, eggs and sugar.


Melatonin PR 3 mg...Melatonin PR 3 mg Prolonged Release by Douglas Laboratories®: Melatonin PR 3 mg provides pure grade melatonin in a prolonged release tablet in support of healthy uninterrupted sleep and overall health. Free of yeast, wheat, gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring and artificial preservatives. Non-GMO vegan formulation.

Melatonin LiposomalMelatonin Liposomal by Quicksilver Scientific: This fast-acting, long-lasting liposomal liquid formula supports the body’s natural melatonin production for healthy sleep. An easy dosing, highly bioavailable and absorbable liquid formulation provides 1 mg of melatonin per serving in support of establishing normal healthy sleep patterns.

The Complete Guide to the Science of Circadian Rhythms. https://endpoints.elysiumhealth.com/the-complete-guide-to-the-science-of-circadian-rhythms-7b78581cbffa
Brain Basics: Understanding Sleep. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Understanding-Sleep
How Blue LEDs Affect Sleep. https://www.livescience.com/53874-blue-light-sleep.html

The Right Amount of Sleep for Optimal Health

SleepOptimalHealthJacquie Eubanks RN BSN

In 1970, the iconic rock band, Chicago, released a single entitled, “Does Anybody Really Know What Time It Is?” Fast forward to 2018, one might ask, “Does anybody really know how much sleep is needed for long-term wellness?” Time marches on and science is still debating the proper amount of sleep for cardiovascular and overall health maintenance. We do know that science has linked poor sleep with chronic health challenges, including memory and concentration issues, weakened immunity, and increased risk of obesity, diabetes, high blood pressure and heart disease. Conversely, research has shown that adequate sleep can strengthen memory, curb inflammation and lower stress, as well as improve mood, spur creativity and support a healthy weight.

Individual sleep requirements are highly variable. As such, health advisors generally recommend that adults strive for an average of seven to nine hours of sleep each night. A new study suggests that sleep duration that is either too short or too long is associated with greater cardiovascular risk factors. Preliminary results from the study, recently published in an online supplement of the journal Sleep Health, suggest that seven may be the magic number when it comes to the relationship between sleep length and long-term cardiovascular health. The study showed that excess heart age appeared to be lowest among adults who reported sleeping an average of seven hours per 24-hour period. Sleeping times less than or greater than seven hours were associated with increased excess heart age, with the highest elevations noted in short sleepers.

Heart age is calculated based on risk factors for heart disease. Common reasons for advanced heart age include normal aging, family history, unhealthy diet, physical inactivity, high blood pressure, diabetes, obesity and smoking. Per the Centers for Disease Control (CDC), one in two men, and two in five women have a heart age five or more years older than their actual age. Those who slept less than seven hours had the highest risk for cardiovascular disease due to the effects of metabolic and endocrine functions, vascular damage, and circadian misalignment. Sleep deprived individuals had higher blood levels of stress hormones, as well as markers of health-damaging inflammation. Researchers also found that those who regularly slept nine or more hours each night had more calcium buildup in their heart artery walls and stiffer leg arteries than those who normally slept seven hours per night.

Research supports protected sleep time for every age group, from children to adolescents, teens and adults. Those who don’t sleep well have greater chances of developing risk factors for poor long-term health, including hypertension, high cholesterol and a higher body mass index. Cardiovascular disease is the number one cause of mortality worldwide and accounts for one of every three deaths in the U.S. Aside from age and family history, cardiovascular disease is largely preventable through addressing modifiable risk factors. Take steps to reduce cardiovascular risk factors by enjoying a whole food healthy diet, becoming physically active, not smoking and managing weight, as well as lowering blood pressure and controlling blood sugar, if needed. To lower heart age and support overall health, aim for seven hours of healthy sleep each night.

Occasional sleeplessness is normal. Nearly one third of Americans have difficulty falling and staying asleep at some point in their lives. However, when infrequent episodes of insomnia escalate to a regular unhealthy routine, poor sleep habits may be to blame. Basic sleep hygiene strategies can include keeping the bedroom cool, dark and comfortable, as well as establishing routine bed and wake up times. Avoid stimulating activities and eating a heavy meal at least three hours before bed. Begin dimming the lights at least an hour before bed to stimulate melatonin production for a good night’s rest.

To find the right amount of sleep for you, experts suggest going to bed at the same time each night for at least one week, while also setting a wake up alarm for the same time each morning. If you find you are waking before the alarm, you have likely gotten sufficient sleep and could go to bed a bit later if desired. If you sleep past the alarm, it’s a good indication that you require more sleep and need to go to bed earlier.

Professional Supplement Center offers these and other high quality formulas to support healthy sleep and overall wellness:

Melatonin Plus 5 mgMelatonin Plus 5 mg by Professional Supplement Center®: This vegetarian biphasic formulation delivers melatonin quickly, then steadily, in support of healthy sleep patterns and synchronization of daily biorhythms. Ingredients confer direct and indirect antioxidant activity. Free of wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, eggs, and artificial colors, sweeteners, and preservatives.

Melatonin PR 3 mg...Melatonin PR 3 mg Prolonged Release by Douglas Laboratories®: This formula provides 3 mg of pure grade melatonin in a prolonged-released tablet in support of healthy restful sleep. Free of yeast, wheat gluten, soy protein, dairy, corn, sodium, sugar, starch, artificial coloring, and artificial preservatives. Non-GMO vegan formulation.

Sleep TimeSleep Time by Nutritional Frontiers: To assist the promotion of restful sleep, this blended formula provides nutrients that support inhibitory neurotransmitter production as well as  promote a sense of wellbeing and reduced anxiety. Vegetarian capsules.


Kavinace Ultra PMKavinace Ultra PM by NeuroScience™: This top selling, highly recommended favorite provides a proprietary blend of ingredients shown to improve the onset and quality of sleep. Powerful ingredients support calming neurotransmitters and hormones important to a healthy sleep cycle to promote restorative sleep and help manage stress and anxiousness.

Study links short and long sleep durations with excess heart age.  https://aasm.org/study-links-short-and-long-sleep-durations-with-excess-heart-age/
How Sleep Deprivation Affects Your Heart. https://aasm.org/study-links-short-and-long-sleep-durations-with-excess-heart-age/
Cardiovascular Disease Risk in Obstructive Sleep Apnea: an Update. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891150/
Getting too little sleep may ‘age’ the heart. https://www.reuters.com/article/us-health-heart-sleep/getting-too-little-sleep-may-age-the-heart-idUSKBN1KZ1UJ
Short and long sleep durations linked with excess heart age. https://www.sciencedaily.com/releases/2018/06/180604093121.htm
Effects of Sleep Deprivation on Your Body. https://www.reuters.com/article/us-health-heart-sleep/getting-too-little-sleep-may-age-the-heart-idUSKBN1KZ1UJ
Heart Age. https://www.cdc.gov/vitalsigns/heartage/index.html


Sleep More – Weigh Less

SleepWeightJacquie Eubanks RN BSN

Interestingly, one of the easiest weight maintenance rules to follow may be getting to bed at a reasonable hour. Mounting evidence shows that those struggling with weight gain may need to optimize their sleep schedules to see a more favorable number on the scale. It’s well known that controlled healthy eating and regular exercise are the top strategies for weight loss and maintenance. To avoid weight gain, prioritizing sleep may be considered an equally important approach, as inadequate sleep is associated with increased body weight and the risk for obesity. Matthew Walker, a professor of psychology and neuroscience at the University of California, Berkeley who studies the effects of sleep on weight, has found that “getting a full night’s sleep is one of the most under-appreciated factors contributing to healthy weight maintenance.”

It appears that our sleep habits directly affect diet and appetite. Researchers at the University of Chicago compared those who slept only four and one-half hours to those who slept eight hours. They found that the those who skimped on sleep did not skimp on calories the next day. In fact, quite the opposite. The short sleepers consumed an additional 400 calories and ate twice the amount of fat and protein, as compared to those who slept an optimal eight hours. Sleep deprivation results in blood alterations of certain lipids, as well as appetite regulating hormones leptin and ghrelin. Controlled studies have shown that deficient sleep leads to decreases in leptin, the satiety hormone, while ghrelin, the hunger and appetite hormone, increases. Recently, it has come to light that less than optimal sleep also results in changes to a lipid known as 2-Arachidonoylglycerol (2AG), an endocannabinoid.

The endocannabinoid system is a unique and ubiquitous cell-signaling system that is just beginning to be understood. Per the National Institutes of Health (NIH), the discovery of endocannabinoids has led to studies on their potential involvement in the physiological control of appetite and energy metabolism. The findings of three large multicenter clinical trials strongly support a pathogenic role of increased endocannabinoid activity in obesity and associated metabolic abnormalities. Studies support that endocannabinoids play a key role in memory, mood, and the brain reward systems, as well as glucose metabolism and energy balance.

Epidemiologic studies established the link between sleep deprivation and its influence on energy balance and body weight regulation processes. While a longer wake cycle results in a slight increase in energy expenditure, it can lead to disproportionate calorie consumption, decreased physical activity and weight gain. The possible involvement of reward system mechanisms may trigger increased unhealthy food intake following sleep restriction. A randomized study showed sleep restriction resulted in increased circulating concentrations of 2AG, widely expressed in the brain’s reward centers and in metabolic organs that stimulate food intake and fat lipogenesis, the metabolic formation of fat.

  • Habitual sleep loss is a major risk factor for weight gain and obesity. Generally, weight gain may occur when one gets fewer than seven hours of sleep nightly. When trying to lose or maintain weight, optimal amounts of healthy sleep may be just as crucial as diet and exercise.
  • Poor sleep causes a disruption of appetite, reward and stress hormones, resulting in increased appetite and negatively affecting the ability to make healthy food choices and control portion sizes.
  • Lack of sleep can result in daytime fatigue and deceased motivation to exercise. Sufficient healthy sleep helps to improve mental and physical performance.
  • Adequate sleep can refresh brain circuits that allow for more optimal food choices, leading to weight control rather than weight gain.
  • Just as inadequate sleep negatively affects energy levels, sufficient sleep can help provide the energy necessary for physical activity.
  • The right amount of sleep encourages proper stress and appetite hormone regulation, as well as a healthy metabolism, the amount of energy the body burns to maintain all cellular processes.
  • Adequate sleep, along with healthy diet and exercise, supports optimal health and decreased risk of developing obesity, diabetes type 2, insulin resistance and metabolic syndrome.

Professional Supplement Center carries these and other high quality products to support healthy sleep and weight maintenance:

Kavinace Ultra PMKavinace Ultra PM by NeuroScience™: This top-selling sleep product specifically targets neurotransmitter imbalances with a unique combination of neurotransmitter precursors, herbal ingredients and enzymatic cofactors that provide effective support for restful sleep. Gluten, soy, yeast and artificial ingredient free, vegetarian formulation.


Adipo-Leptin...Adipo-Leptin Benefits™ by DaVinci Laboratories of Vermont: This product offers evidence-based ingredients that support hormone balance relative to appetite and weight management. Gluten and soy free, Non-GMO vegetarian formulation.


5HTP Supreme5-HTP Supreme™ by Designs for Health: This higher dosage product supplies vitamin B6 and 5-HTP in support of appetite control, reduced cravings, insomnia, improved mood and overall neurotransmitter metabolism. Wheat, soy, dairy and preservative free, Non-GMO vegetarian formulation. This product is not recommended for those taking SSRI’s or MAO inhibitors.


Melatonin PR 3 mg...Melatonin PR 3 mg Prolonged Release by Douglas Laboratories: This natural hormone nutrient helps to regulate the sleep/wake cycle, supports normal immune function, and provides free radical protection. One serving provides 3 mg of pure pharmaceutical grade melatonin in a prolonged release tablet. Gluten, wheat, soy, dairy, sugar and artificial ingredient free vegan formulation.

Molecular ties between lack of sleep and weight gain. https://www.nih.gov/news-events/nih-research-matters/molecular-ties-between-lack-sleep-weight-gain
The Endocannabinoid System as an Emerging Target of Pharmacotherapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/
Endocannabinoids. http://emedicine.medscape.com/article/1361971-overview#a1
Hungry for Sleep: A Role for Endocannabinoids? https://academic.oup.com/sleep/article/39/3/495/2453912/Hungry-for-Sleep-A-Role-for-Endocannabinoids
Metabolic effects of sleep disruption, links to obesity and diabetes. https://www.ncbi.nlm.nih.gov/pubmed/24937041
Impact of insufficient sleep on total daily energy expenditure, food intake and weight gain. https://www.ncbi.nlm.nih.gov/pubmed/24937041
Does Your Sleeping Schedule Affect Your Metabolism? http://healthyeating.sfgate.com/sleeping-schedule-affect-metabolism-8571.html
Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. https://www.ncbi.nlm.nih.gov/pubmed/22357722