Tag Archives: Ubiquinol-QH 100 mg by Pure Encapsulations

Do You CoQ10?

Do you CoQ10Jacquie Eubanks RN BSN

Vital for life and healthy functioning, enzymes are biological molecules, largely proteins, that significantly increase the rate of chemical reactions that take place within cells. Although cells may contain thousands of enzymes, enzymes are highly selective catalysts. Each enzyme has a very specific interaction that determines which of the many possible reactions take place within the cell. Were it not for these enzymatic catalysts, most biochemical reactions would be so slow that they would not occur under the mild temperature and pressure compatible with life. To put this in perspective, enzymes accelerate reaction rates by well over a million-fold. In the absence of enzymes, catalysis that can occur in fractions of seconds would otherwise take years.

In general, coenzymes are necessary to support the various biochemical functions of enzymes. Naturally synthesized by the body, coenzyme Q10 (CoQ10) is an important and effective fat-soluble cellular antioxidant that protects cell membranes, mitochondrial DNA and low density lipoproteins (LDL) from oxidative damage. CoQ10 is also known by its reduced form, ubiquinol; aptly named because it is found in virtually all bodily cells and is therefore ubiquitous within the body. It is a crucial participant in the chain of metabolic reactions that generate adenosine triphosphate (ATP), the main source of energy for cellular processes. It stands to reason then that the highest concentrations of CoQ10 are found in high energy organs, including the heart, liver, pancreas, kidneys and adrenals.

Why supplement with CoQ10?

  • Tissue concentrations of CoQ10 have been found to gradually decline after age 30. The conversion of CoQ10 to ubiquinol becomes less efficient during mid-life.
  • The body must reduce CoQ10 to ubiquinol in order to be used for cellular energy production, necessary for optimal organ and bodily functions.
  • Decreased plasma concentrations have been observed in individuals with diabetes, cancer and congestive heart failure.
  • Those who are taking lipid lowering medications, or statins, are at a particular risk for deficiency because statins inhibit activity of an enzyme critical to CoQ10 biosynthesis, and thereby decrease circulating CoQ10.
  • For people on statin therapy, a low level of CoQ10 can contribute to statin-related side effects, such as fatigue, joint aches and muscle cramps.
  • As CoQ10 is found in high concentration in heart muscle cells, deficiency is associated with cardiovascular problems, including angina, arrhythmia, heart failure and high blood pressure.
  • Problems with blood sugar regulation, periodontal health and stomach ulcers have also been associated with CoQ10 deficiency.
  • CoQ10 or ubiquinol supplementation may be especially helpful for any adult taking statin medications, those with a family history of heart disease and individuals at risk for cardiovascular disease.
  • Although more studies are needed, CoQ10 supplementation shows promise as an inhibitor of lipoprotein oxidation in blood vessel walls and the formation of atherosclerosis.
  • For otherwise healthy individuals, CoQ10 taken as a preventive measure may help maintain a healthy cardiovascular system. Studies show that supplementation may significantly increase good HDL cholesterol even among those taking statins. As well, supplementation may lower levels of inflammatory biomarkers shown to be risk factors for cardiovascular and chronic diseases.
  • The heart requires a significant amount of cellular energy for both contraction and relaxation of the heart muscle. Lacking CoQ10 to produce ATP, heart function would be compromised.
  • CoQ10 has an excellent safety profile with no reports of significant adverse side effects. Individuals taking anticoagulant medications should consult a healthcare practitioner before taking CoQ10, as it may decrease the medication’s effectiveness.

Small amounts of CoQ10 may be obtained by foods found in a healthy diet, such as chicken, meat, fish, whole grains, olive oil and cruciferous vegetables. As CoQ10 is fat-soluble,  supplements should be taken with a meal containing fat for best absorption. Individuals over 40 years of age should consider the advantages of supplementing with the ubiquinol form of CoQ10, as it requires no further conversion by the body to be utilized. Adequate CoQ10 levels support the cellular energy the body needs to maintain overall health and wellbeing. Energy production associated with ubiquinol benefits whole body health by providing the cellular energy necessary for the heart and other organs to function at optimal levels.

Professional Supplement Center offers these and other high quality Ubiquinol formulas:

Ubiquinol-QH 100 mgUbiquinol-QH 100 mg by Pure Encapsulations®: This hypoallergenic formula supplies ubiquinol, the active, readily-absorbable antioxidant form of CoQ10 in support of cellular energy production, antioxidant protection and cardiovascular health. Gluten free, Non-GMO formulation.

Ubiquinol-QHUbiquinol-QH by Douglas Laboratories®: Each softgel supplies 100 mg of CoQ10 as ubiquinol in support of cardiovascular health and function. Free of yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch and artificial coloring, preservatives and flavoring.

UBQH Ubiquinol 100...UBQH™ Ubiquinol 100 mg by Integrative Therapeutics®: UBQH™ supplies the reduced active-from of CoQ10 in support of cellular energy production and overall wellness. Free of gluten, wheat, dairy, corn, sugar, yeast, salt and artificial flavoring and coloring.

 

Ubiquinol 100 mgUbiquinol 100 mg by Protocol for Life Balance®:  This highly bioavailable, naturally fermented Kaneka Ubiquinol™ is formulated to support normal cardiovascular and neuronal functions. Free of gluten, wheat, soy, milk, egg, fish and shellfish.

 

References:
The Central Role of Enzymes as Biological Catalysts. https://www.ncbi.nlm.nih.gov/books/NBK9921/
Ubiquinol. http://blog.professionalsupplementcenter.com/ubiquinol/
Coenzyme Q10. https://lpi.oregonstate.edu/mic/dietary-factors/coenzyme-Q10
CoQ10 and Ubiquinol Health Benefits. http://blog.professionalsupplementcenter.com/coq10-and-ubiquinol-health-benefits/
Ubiquinol CoQ10 Research Overview. https://ubiquinol.org/clinical-studies
Coenzyme Q10 Supplementation in Aging and Disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807419/

Brain Nutrients – Food for Thought

FoodForThoughtJacquie Eubanks RN BSN

While we primarily conceive of nutrition in terms of energy production and support for building and repair processes, throughout history, many cultures have traditionally used plant foods and spices as a means for prevention and protection against disease. In modern times, the ability of dietary factors to influence brain health are only now beginning to be recognized. Over the last decade, research has provided evidence that dietary components may influence mechanisms and molecular systems that maintain mental function, more specifically synaptic plasticity. Synapses or junctions, where virtually all important brain activity emerges, effectively control neuronal communication. Plasticity is the ability of the brain to adapt to new information; synaptic plasticity is the brain’s ability to strengthen or weaken the synaptic function as a result of learning. For example, repeating song lyrics strengthens the related connections in the brain that make it possible to easily recall the words.

A sharp mind and memory formation depend on the vitality of the brain’s network of interconnecting neurons. Research has established that synaptic activity, including synapse-specific modifications of synaptic strength, plays a vital role in learning and memory. The ability to learn and remember, as well as other mental and emotional processes, can be influenced by  factors such as stress, lack of stimulation or neurotoxins that may cause synapse dysfunction. A balanced diet, adequate amounts of physical activity, proper sleep, and healthy environmental interaction appear to have the potential to alter brain heath and mental function. Nutrients that influence cognition act on the necessary cellular processes for the maintenance of brain health. Encouraging results of clinical and preclinical studies raise the possibility that dietary interventions may be a viable strategy for enhancing cognitive abilities, protecting the brain from damage, promoting repair, and counteracting the effects of aging.

Adults of all ages looking to preserve brain heath and function throughout their lifespan, should consider following a healthy lifestyle to help protect and strengthen the synapses that keep minds active and alert. Lifestyle tips for healthy brain function include stress reduction and relaxation techniques, brain stimulation though demanding intellectual tasks, cardiovascular exercise to oxygenate the brain, adequate sleep, not smoking, taking alcohol in moderation and eating a nutritious diet that includes brain supportive nutrients. Per the National Institutes of Health (NIH), select nutrients have the capacity to affect neural pathways associated with synaptic plasticity that positively affects cognitive function. These dietary components have been identified as having effects on membrane fluidity, the regulation of neurotransmitter pathways, synaptic transmission and signal-transduction pathways.

DHA Omega-3 essential fatty acids, specifically DHA, are normal constituents of cell membranes and are essential for normal brain function. Dietary consumption of omega-3 fatty acids is one of the best-studied correlations between food and brain evolution. As the human body is not efficient at synthesizing DHA, we are largely dependent on dietary sources, such as oily fish, shellfish and algae. Dietary deficiency of omega-3 fatty acids has been associated with increased risk of mental health disorders, including dementia and depression. DHA may enhance cognitive abilities by facilitating synaptic plasticity, or through its positive effects on metabolism, glucose utilization, and mitochondrial function.

Turmeric/Curcumin – Studies suggest that curcumin has bioactive antioxidant, anti-inflammatory and neuro-protective effects. Population studies have shown that those who regularly consume curcuminoids as part of their traditional cuisine, such as in India and Asia, scored significantly better on cognitive function tests. Chronic low-grade inflammation plays a major role in many degenerative conditions. Curcumin’s strong anti-inflammatory properties may inhibit inflammation at the molecular level to help prevent or fight chronic inflammation. Curcumin may also boost levels of brain-derived neurotrophic factor (BDNF), which supports synaptic plasticity and cognitive function, as well as the survival of existing neurons and the differentiation of new neurons.

Flavonoids – Flavonoids, phytochemicals found in a variety of fruits and vegetables, have been identified as promising bioactive compounds capable of influencing certain aspects of brain function, including cerebrovascular blood flow, and synaptic plasticity and strengthening. Dietary flavonoids are believed to have the potential to protect against neurotoxin damage, suppress neuroinflammation, and promote memory, learning and cognitive function.

B vitamins – Per the NIH, B complex vitamins are absolutely essential for every aspect of brain function. These synergistic micronutrients work at a cellular level to support energy production, healthy mood and cognitive performance, as well as DNA/RNA synthesis and repair, and the synthesis of numerous neurochemicals and signaling molecules.

CoQ10/Ubiquinol – Found in virtually all cell membranes, CoQ10 (ubiquinone) is a powerful antioxidant and a vital participant in oxygen utilization and cellular energy production. By aiding energy production and protecting organ cells from oxidative stress and free radical damage, CoQ10 supports the overall health of all bodily cells, organs and tissues. Animal studies have shown that oral administration of CoQ10 can exert neuroprotective effects that may prove useful in the future treatment of neurodegenerative disease.

Professional Supplement Center carries these and other high quality supplements in support of brain and overall health:

ProDHA 1000 mg...ProDHA 1000 mg Strawberry by Nordic Naturals®: This high potency formula offers research- backed benefits for brain, eye, and nervous system health, as well as emotional wellbeing. Sourced from purified deep sea fish oil. Natural strawberry flavor. Naturally preserved with rosemary extract and d-alpha tocopherol. Gluten free, no artificial ingredients, Non-GMO verified.

Ubiquinol-QH 100 mgUbiquinol-QH 100 mg by Pure Encapsulations®: This product provides Kaneka QH™, a readily absorbable, active antioxidant form of CoQ10, in support of cellular energy production, cardiovascular health and free radical protection. Gluten free, hypoallergenic, Non-GMO formulation.

Curcumin 500 with...Curcumin 500 with Bioperine by Pure Encapsulations®: This product supplies 500 mg of turmeric standardized to contain 95% curcuminoids in support of a healthy inflammatory response, cellular health, and healthy liver, colon and musculoskeletal function. Bioperine® is added for enhanced bioavailability and absorption. Gluten free, hypoallergenic, Non-GMO vegan formulation.

FlavonALLFlavonAll by Douglas Laboratories®: This broad-spectrum flavonoid-based supplement delivers eight of the most concentrated and well-researched standardized plant extracts highly regarded for their beneficial antioxidant properties. Ingredients include Pycnogenol®, as well as grape seed, bilberry, and milk thistle extracts. Soy free, vegan formulation.

Active B-ComplexActive B-Complex by Integrative Therapeutics®: This product provides the full complement of bioavailable B vitamins in support of numerous biochemical processes and overall healthy function. Gluten, wheat, dairy, soy and artificial ingredient free, vegetarian formulation.

References:
Brain foods: the effects of nutrients on brain function. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805706/
Boost your memory by eating right. https://www.health.harvard.edu/mind-and-mood/boost-your-memory-by-eating-right
Nutrients for a Sharp Memory. http://www.todaysdietitian.com/newarchives/1217p24.shtml
4 Types of Foods to Help Boost Your Memory. https://www.eatright.org/health/wellness/healthy-aging/memory-boosting-foods
Do Memory Problems Always Mean Alzheimer’s Disease? https://www.nia.nih.gov/health/do-memory-problems-always-mean-alzheimers-disease
The synaptic plasticity and memory hypothesis: encoding, storage and persistence. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843897/
10 Proven Health Benefits of Turmeric and Curcumin. https://www.healthline.com/nutrition/top-10-evidence-based-health-benefits-of-turmeric
Flavonoids and brain health: multiple effects underpinned by common mechanisms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775888/
Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21173/

 

Strategies To Address Dementia Risk

DementiaJacquie Eubanks RN BSNDementia is a general term for the loss of memory and intellectual abilities. Alzheimer’s disease is the 6th leading cause of death in the U.S., and the most common form of age-related dementia, contributing to 70% of the almost 50 million cases worldwide. Alzheimer’s and other forms of dementia are expected to dramatically increase as the population ages, with some estimates predicting 150 million cases by 2050. While there is currently no cure for dementia, a large body of research suggests that modifiable risk factors may hold the most promise for prevention of the progressive decline in mental function due to generalized brain deterioration.

No strategies are guaranteed to protect long term brain health. However, researchers have reviewed a large body of evidence, and have identified nine controllable risk factors, through various stages of life, that affect the likelihood of developing dementia. The study, recently published in The Lancet, brought together 24 international experts to review existing dementia research and determine strategies for prevention and intervention. As well, they looked for ways to improve care for those already living with the disease. While the focus has been on developing medicines for prevention and treatment, non-pharmaceutical preventative approaches that strengthen brain networks early in life may help reduce dementia cases by one-third.

Alzheimer’s causes a gradual decline in memory, thinking, and reasoning skills. There’s no question that many more trials and ongoing research into developing treatments is necessary, yet the researchers considered the scientific evidence strong enough to suggest that preventing dementia and age-related cognitive decline might be possible. Of course, there are no guarantees, and prevention needs to start before there are signs of decline, preferably before middle age.

The nine modifiable risk factors that affect the likelihood of developing dementia are:

  • Hypertension management. Controlled blood pressure levels aid in preserving brain blood vessel health. This is considered most effective when initiated early on in life, but management of blood pressure is advised at every age.
  • Increased physical activity. Aerobic exercise is associated with a reduced risk of cognitive impairment and dementia. Vascular risk factors are well known to be reduced by aerobic exercise. Evidence suggests that physical activity may slow the progression of neurodegenerative processes and age-related loss of synapses in the brain.  
  • Cognitive training. Mental stimulation that challenges the brain helps to strengthen the brain’s networks. Getting a good education in early life, and continuing at least through high school, may have a direct effect on the wiring of the brain. Challenging the brain may increase “cognitive reserve” built through a lifetime of continued learning and curiosity. Research has shown that those with greater cognitive reserve are better able to fend off degenerative brain changes.
  • Lose weight if needed. Being overweight or obese at midlife independently increases the risk of dementia, Alzheimer’s, and vascular dementia in later life.
  • Prevent or control diabetes. Studies suggest that people with type 2 diabetes are at a higher risk of developing Alzheimer’s and vascular dementia. Taking steps to manage diabetes may help to avoid potential cognitive decline.
  • Avoid or address hearing loss. It remains unclear whether hearing loss is the result of changes linked to dementia or whether hearing loss itself contributes to cognitive decline. Research suggests that those who experience hearing loss may be at greater risk of cognitive problems later in life than those without auditory problems.
  • Manage depression. Depression has been proposed as both a risk factor for and an early symptom of dementia. Approximately half of those with late-onset depression have cognitive impairment.
  • Remain socially active. Studies show that social interaction is key to mental health, and that those with larger social networks are 25 percent less likely to develop dementia than those with smaller networks.
  • Quit smoking. Smoking is damaging to cardiovascular and overall health and may lead to cognitive decline. Studies show that smokers have a 40 percent increased risk of Alzheimer’s and vascular dementia. Smoking causes oxidative stress, which appears to promote the formation of the amyloid plaques and neurofibrillary tangles in the brain that are closely associated with Alzheimer’s disease.

Professional Supplement Center offers these and other high quality supplements for brain health support:

Acetyl L-Carnitine...Acetyl L-Carnitine 500 mg by Douglas Laboratories®: This naturally occurring metabolite helps to maintain cellular membrane stability and restore age-related membranal changes, supporting brain and nervous system functions. As an antioxidant, it scavenges harmful superoxide radicals. Gluten, yeast, wheat, soy, dairy, corn, sodium, sugar, starch, and artificial ingredient free.

 

Ubiquinol-QH 100 mgUbiquinol QH 100 mg by Pure Encapsulations®: This product supplies Kaneka QH™ CoQ10 in its active, readily-absorbable antioxidant form; and supports cellular energy production, antioxidant protection, cardiovascular health and physical activity. Gluten free, Non-GMO formulation.

 

Phosphatidylserine...Phosphatidylserine Soy Free by Integrative Therapeutics®: Found primarily in the cell membranes of neurons, and in high concentrations in the brain and nervous system tissues, phosphatidylserine supports cognitive function and mental clarity. Gluten, yeast, wheat, soy, dairy, corn, sodium, sugar, starch, and artificial ingredient free.

 

AntiOxidant FormulaAntiOxidant Formula by Pure Encapsulations®: This synergistic, broad spectrum antioxidant formulation is designed to promote cellular health and support the body’s natural free radical defense system. Gluten and soy free, Non-GMO.

 

Longevity NutrientsLongevity Nutrients by Pure Encapsulations®: This hypoallergenic, nutrient-rich, highly bioavailable multivitamin, multi-mineral, and trace element supplement is designed for men and women over age 60 in support of healthy aging and optimal health. Gluten free, Non-GMO vegetarian formulation.

 

Vitamin D3 5000Vitamin D3 5000 by Neurobiologix: Essential for good health in aging adults, vitamin D deficiency is associated with osteoporosis and cardiovascular disease, and may also impact the development of diabetes, hypertension, dementia and Alzheimer’s. Wheat, gluten, soy, corn protein, yeast, dairy, and artificial ingredient free.

References:
Defeating Alzheimer’s disease and other dementias. http://www.thelancet.com/commissions/dementia
One-third of dementia cases could be prevented, report says. http://www.cbsnews.com/news/one-third-of-dementia-cases-could-be-prevented-alzheimers-report/
10 Early Signs and Symptoms of Alzheimer’s. http://www.alz.org/10-signs-symptoms-alzheimers-dementia.asp
2016 Alzheimer’s Statistics. http://www.alzheimers.net/resources/alzheimers-statistics/
Can Dementia Be Prevented? Education May Bolster Brain Against Risk. http://www.npr.org/sections/health-shots/2016/02/11/466403316/can-dementia-be-prevented-education-may-bolster-brain-against-risk
What is cognitive reserve? http://www.health.harvard.edu/mind-and-mood/what-is-cognitive-reserve
Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258000/
Midlife overweight and obesity increase late-life dementia risk. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100125/
Diabetes and Alzheimer’s linked. http://www.mayoclinic.org/diseases-conditions/alzheimers-disease/in-depth/diabetes-and-alzheimers/art-20046987?pg=2
The complex relationship between depression and dementia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039168/
Friends Make You Smart. http://www.aarp.org/health/brain-health/info-11-2008/friends-are-good-for-your-brain.html
Smoking and Dementia: What to Know. https://www.healthafter50.com/memory/article/smoking-and-dementia-what-to-know